{"id":"W2141866322","doi":"10.1093/jnci/djp473","title":"Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers","year":2009,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medical Research Council; National Cancer Institute; University of Toronto; University of Melbourne; Dartmouth College; Imperial College London; Institute of Genetics; Ohio State University; National Institutes of Health; Universiteit Leiden; Cancer Research UK; University of Minnesota","keywords":"Lynch syndrome; Medicine; MSH6; Population; Internal medicine; Cancer; Colorectal cancer; Endometrial cancer; Hazard ratio; Germline mutation; Oncology; Gynecology; Confidence interval; Mutation; Genetics; Biology; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008220436,0.0003005086,0.0002584461,0.001018813,0.0002656423,0.0003427403,0.0002097768,0.0004457138,0.002238565],"category_scores_gemma":[0.003383667,0.0002906675,0.0006385387,0.0004476074,0.0002551214,0.0002286017,0.0003699245,0.0005004077,0.0001868969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002150821,"about_ca_system_score_gemma":0.0002638851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002807837,"about_ca_topic_score_gemma":0.002448174,"domain_scores_codex":[0.9996171,0.0001099354,0.00002719811,0.0001136724,0.00005576391,0.00007633668],"domain_scores_gemma":[0.9977858,0.0008271898,0.0008268405,0.0001324326,0.0001348105,0.0002930024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002963357,0.000008103163,0.9961956,0.00001469262,0.0001061853,0.0003037009,0.00005815801,0.0001738286,0.0003713187,0.00004173513,0.00015418,0.002276306],"study_design_scores_gemma":[0.00002114295,0.0002233611,0.9944993,0.0000195033,0.0002156211,0.003367403,0.0001117593,0.000494577,0.0002516297,0.0001787033,0.0006079898,0.000008938908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975613,0.001124566,0.0003056773,0.00007342511,0.000009331974,0.00000848816,0.0003863614,0.00001246226,0.000518488],"genre_scores_gemma":[0.9991467,0.0002681035,0.0001717249,0.0000126017,0.000007402003,0.000004835565,0.0002525806,0.000003232185,0.0001329746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002807837,"threshold_uncertainty_score":0.007488787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1151758469867769,"score_gpt":0.4114371212290399,"score_spread":0.296261274242263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}