{"id":"W2141887125","doi":"10.1124/dmd.105.006742","title":"DETERMINATION OF THE ENZYME(S) INVOLVED IN THE METABOLISM OF AMIODARONE IN LIVER AND INTESTINE OF RAT: THE CONTRIBUTION OF CYTOCHROME P450 3A ISOFORMS","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Cytochrome P450; Microsome; CYP3A4; CYP3A; Metabolite; Metabolism; CYP1A2; In vivo; Isozyme; Pharmacokinetics; Enzyme; Drug metabolism; Pharmacology; Internal medicine; Endocrinology; Chemistry; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845321,0.0003127035,0.0003492246,0.0005563179,0.0002371471,0.0002585233,0.0001683234,0.0003358169,0.00115491],"category_scores_gemma":[0.0002799111,0.0002467042,0.0004314793,0.0003425972,0.0002887154,0.000404821,0.0001288662,0.0006513946,0.0003472654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002253585,"about_ca_system_score_gemma":0.0002943436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926401,"about_ca_topic_score_gemma":0.002523307,"domain_scores_codex":[0.9999133,0.00001512,0.000005906127,0.00002461253,0.00001618079,0.00002478279],"domain_scores_gemma":[0.9997076,0.00005560815,0.00006185124,0.0000333799,0.00005561197,0.0000858157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00149105,0.00004793626,0.006993543,0.00006300129,0.00004214743,0.0001395395,0.00004910023,0.00009270548,0.9853158,0.0002409087,0.00005122428,0.005472984],"study_design_scores_gemma":[0.00005368819,0.0009333413,0.1237402,0.00001427335,0.0001863842,0.0006802942,0.0001484903,0.001273379,0.8706845,0.0002616492,0.00200835,0.0000153989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913821,0.00220453,0.004445907,0.0001142149,0.00002649074,0.00002792475,0.0006198253,0.00004550497,0.001133627],"genre_scores_gemma":[0.9904856,0.001562935,0.004230192,0.00005092867,0.00002762872,0.00003790433,0.0009606282,0.00002677527,0.00261738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926401,"threshold_uncertainty_score":0.003863513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02859904623713256,"score_gpt":0.3363189644912888,"score_spread":0.3077199182541562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}