{"id":"W2141887125","doi":"10.1124/dmd.105.006742","title":"DETERMINATION OF THE ENZYME(S) INVOLVED IN THE METABOLISM OF AMIODARONE IN LIVER AND INTESTINE OF RAT: THE CONTRIBUTION OF CYTOCHROME P450 3A ISOFORMS","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Cytochrome P450; Microsome; CYP3A4; CYP3A; Metabolite; Metabolism; CYP1A2; In vivo; Isozyme; Pharmacokinetics; Enzyme; Drug metabolism; Pharmacology; Internal medicine; Endocrinology; Chemistry; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001968307,0.0001981077,0.0004990416,0.0001893177,0.00009422654,0.00000841934,0.0002999322,0.0001400051,0.00002879813],"category_scores_gemma":[0.000181834,0.0001132992,0.0001029828,0.0004867519,0.000569066,0.0002032457,0.0001199578,0.0003638442,5.229444e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001239102,"about_ca_system_score_gemma":0.00004974194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001570155,"about_ca_topic_score_gemma":0.0002162097,"domain_scores_codex":[0.9976636,0.0008545623,0.0007920766,0.000198498,0.0002601396,0.0002311346],"domain_scores_gemma":[0.9984186,0.000553353,0.0005585164,0.0002273291,0.000192743,0.00004940512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006965739,0.0008171436,0.008825959,0.000173197,0.00006695016,0.000002037808,0.01044547,0.0003335424,0.9163444,0.02031474,0.00008279189,0.0418972],"study_design_scores_gemma":[0.003339634,0.00002894743,0.5035588,0.00005819813,0.0004390445,0.000009700856,0.0005105798,0.008882807,0.4785522,0.001764236,0.002722865,0.0001330232],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806987,0.01721656,0.0001702033,0.0007307705,0.0002078253,0.000736354,0.0001067499,0.000004632257,0.0001281702],"genre_scores_gemma":[0.9964615,0.002818767,0.0001385998,0.0003812503,0.0001016647,0.00004701698,0.00002471562,0.000009856741,0.00001664942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4947328,"threshold_uncertainty_score":0.4620209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02859904623713256,"score_gpt":0.3363189644912888,"score_spread":0.3077199182541562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}