{"id":"W2141892812","doi":"10.1186/bcr3483","title":"Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Pennsylvania Department of Health; Susan G. Komen for the Cure","keywords":"Signal transduction; PI3K/AKT/mTOR pathway; Protein kinase B; Cell growth; Cell biology; Cancer research; Biology; MAPK/ERK pathway; Kinase; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005952717,0.0003201166,0.0003506949,0.0001449261,0.0003083842,0.0001695684,0.0003138137,0.0002550483,0.0007349427],"category_scores_gemma":[0.00002081538,0.0002635559,0.00005848481,0.0004054037,0.0002795454,0.00003082911,0.0002277767,0.0003755261,0.00004143381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457225,"about_ca_system_score_gemma":0.0008248863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002291346,"about_ca_topic_score_gemma":0.0005950265,"domain_scores_codex":[0.9972168,0.0002366383,0.00029864,0.000745584,0.0006328721,0.0008694257],"domain_scores_gemma":[0.9980041,0.00002751668,0.0001171924,0.0003881034,0.001111447,0.0003515884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003596971,0.0001202705,0.005476029,0.00007506077,0.0002334896,2.950886e-7,0.0002905231,0.00006663775,0.955057,0.000008665033,0.01707707,0.02123526],"study_design_scores_gemma":[0.003058496,0.0001095554,0.2388557,0.0003412957,0.00008771571,0.00003426088,0.0003804395,0.00006153678,0.4034078,0.00001571714,0.3527699,0.0008776583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886724,0.00811116,0.0000159058,0.0009325196,0.001173597,0.0006212599,0.0001861956,0.00002756745,0.0002594304],"genre_scores_gemma":[0.9863642,0.001925628,0.0001698159,0.0002520455,0.005269691,0.0005409443,0.0001240135,0.0000990288,0.005254594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5516493,"threshold_uncertainty_score":0.9999816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885206949620861,"score_gpt":0.2753162656027632,"score_spread":0.2564641961065546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}