{"id":"W2141892812","doi":"10.1186/bcr3483","title":"Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Pennsylvania Department of Health; Susan G. Komen for the Cure","keywords":"Signal transduction; PI3K/AKT/mTOR pathway; Protein kinase B; Cell growth; Cell biology; Cancer research; Biology; MAPK/ERK pathway; Kinase; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377601,0.0002862296,0.0001723167,0.0003196135,0.0001768849,0.0002702951,0.0001380012,0.0002077842,0.002173406],"category_scores_gemma":[0.0001086244,0.00007669646,0.000180737,0.0002794528,0.0001482538,0.0001109693,0.0001738961,0.0002944884,0.0007166519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577652,"about_ca_system_score_gemma":0.0002906022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007818305,"about_ca_topic_score_gemma":0.0007048475,"domain_scores_codex":[0.9999024,0.00001549585,0.000007109919,0.00001798373,0.0000269176,0.00003005345],"domain_scores_gemma":[0.9999112,0.000007894991,0.0000340054,0.000006039304,0.00001910632,0.00002188133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002319632,0.00005253787,0.004500012,0.0001717378,0.00002261792,0.0002663791,0.00004457275,0.00004774868,0.9805227,0.0003235099,0.0005783166,0.0132377],"study_design_scores_gemma":[0.0001195521,0.0008420714,0.2768587,0.0001240779,0.0002141242,0.002822632,0.0003458557,0.001827042,0.6637095,0.0006255411,0.05247876,0.0000321699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9235282,0.06124485,0.00365805,0.00097172,0.0001453105,0.00008278894,0.001075986,0.0002736198,0.0090195],"genre_scores_gemma":[0.9668661,0.01997761,0.00211781,0.0002001976,0.00008112607,0.00008148943,0.00122594,0.00001733584,0.00943221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173406,"threshold_uncertainty_score":0.007270753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885206949620861,"score_gpt":0.2753162656027632,"score_spread":0.2564641961065546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}