{"id":"W2141918542","doi":"10.1093/hmg/ddq288","title":"Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Ontario Institute for Cancer Research; University of Ottawa","funders":"Canadian Institutes of Health Research; Ministry of Education, Science and Technology; Heart and Stroke Foundation of Canada; McGill University; National Research Foundation of Korea; National Research Foundation; Parkinson's Disease Foundation","keywords":"Biology; PINK1; Mitochondrion; Programmed cell death; Oxidative stress; Parkin; Cell biology; Phenotype; Autophagy; Reactive oxygen species; Mitochondrial DNA; Mitochondrial ROS; Genetics; Gene; Mitophagy; Parkinson's disease; Apoptosis; Disease; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005553777,0.0002734911,0.0002996947,0.00007199746,0.0001588833,0.00002568737,0.0003001051,0.0001493106,0.0001273794],"category_scores_gemma":[0.00005814367,0.0002076257,0.0003551776,0.0001487465,0.0002032099,0.00001721466,0.0001413625,0.0002694612,0.00001846869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005403816,"about_ca_system_score_gemma":0.0001836861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001517194,"about_ca_topic_score_gemma":0.00004659208,"domain_scores_codex":[0.9983717,0.00006089347,0.0002942613,0.0004141344,0.0005313752,0.0003276902],"domain_scores_gemma":[0.9982194,0.00001480912,0.0001491173,0.001107607,0.0001463816,0.000362637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003077585,0.001201521,0.08082798,0.0001256287,0.0004728127,0.0007932997,0.0001272128,0.00006886548,0.9074249,0.00611788,0.0003045658,0.002227627],"study_design_scores_gemma":[0.004834123,0.0003155446,0.8843785,0.00008276979,0.001445323,0.00007438564,0.00002408627,0.002789553,0.07666754,0.0052906,0.02361634,0.0004812235],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962721,0.000649246,0.0008563171,0.0002564762,0.0006732712,0.0006515238,0.0001283099,0.00003845137,0.0004742669],"genre_scores_gemma":[0.9953315,0.00004992114,0.003408937,0.0003519822,0.0002276754,0.00003743247,0.0001357062,0.00006686124,0.0003900267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8307573,"threshold_uncertainty_score":0.8466729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103799523503935,"score_gpt":0.2511523078559784,"score_spread":0.2407723555055849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}