{"id":"W2141918542","doi":"10.1093/hmg/ddq288","title":"Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Ontario Institute for Cancer Research; University of Ottawa","funders":"Canadian Institutes of Health Research; Ministry of Education, Science and Technology; Heart and Stroke Foundation of Canada; McGill University; National Research Foundation of Korea; National Research Foundation; Parkinson's Disease Foundation","keywords":"Biology; PINK1; Mitochondrion; Programmed cell death; Oxidative stress; Parkin; Cell biology; Phenotype; Autophagy; Reactive oxygen species; Mitochondrial DNA; Mitochondrial ROS; Genetics; Gene; Mitophagy; Parkinson's disease; Apoptosis; Disease; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038719,0.0002933435,0.0001813112,0.0002220695,0.0001750448,0.0002750976,0.0001208147,0.0002126405,0.00054932],"category_scores_gemma":[0.000131281,0.0000919995,0.0001181554,0.0001351249,0.0002985684,0.0001823414,0.0001629757,0.0002951417,0.0001583535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717139,"about_ca_system_score_gemma":0.0001609247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003570462,"about_ca_topic_score_gemma":0.0007506082,"domain_scores_codex":[0.9999398,0.00001258688,0.000007222237,0.00001391926,0.00001600195,0.000010418],"domain_scores_gemma":[0.9999365,0.00001115962,0.00003030678,0.000005846173,0.000003710933,0.00001254672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005215269,0.0000236929,0.0003039141,0.00005051501,0.000008075552,0.000142489,0.00001327663,0.0001087893,0.9972116,0.0001672265,0.00005909945,0.00185909],"study_design_scores_gemma":[0.0000265595,0.000441945,0.01051869,0.00001047754,0.00003882474,0.002217327,0.00004390529,0.001086545,0.9805042,0.000411629,0.004693645,0.000006371338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929536,0.003858799,0.002055122,0.0001494611,0.00002435791,0.00001175921,0.0001351392,0.00005312778,0.0007584812],"genre_scores_gemma":[0.9950205,0.002825288,0.001201331,0.00003971983,0.00000743409,0.000006575156,0.0001631619,0.000009021581,0.0007269568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00054932,"threshold_uncertainty_score":0.001971364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103799523503935,"score_gpt":0.2511523078559784,"score_spread":0.2407723555055849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}