{"id":"W2141919622","doi":"10.1172/jci33166","title":"No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"X-inactivation; Biology; Skewed X-inactivation; Offspring; X chromosome; Haematopoiesis; Genetics; Immunology; Pregnancy; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001890329,0.0001038982,0.0003008086,0.0001033102,0.00002622094,0.00001430685,0.0001907178,0.0001731628,0.00003728065],"category_scores_gemma":[0.001344917,0.00009246651,0.0001695915,0.0001219771,0.00008769234,0.00003182995,0.00003356063,0.0002109626,0.000003902121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001618061,"about_ca_system_score_gemma":0.00009569975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002020941,"about_ca_topic_score_gemma":0.0000355395,"domain_scores_codex":[0.9978517,0.0001030706,0.001422248,0.0001740726,0.0003009955,0.0001478957],"domain_scores_gemma":[0.9983156,0.0002291286,0.0008120624,0.0001405855,0.0003409852,0.0001616453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004963939,0.0001975645,0.6473464,0.0001130858,0.00005095901,0.00001132048,0.0005648605,0.00005707725,0.3323665,0.00008066418,0.0001660407,0.01854912],"study_design_scores_gemma":[0.0006632095,0.001243582,0.6166893,0.0004908986,0.00001806147,0.000005408124,0.0002631342,0.00002850736,0.3791784,0.0003552111,0.0009484977,0.0001158077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948322,0.00008982941,0.00393241,0.0005867052,0.0002610915,0.00009871529,0.000002192402,0.000002523674,0.0001943867],"genre_scores_gemma":[0.9965384,0.0002196353,0.001409893,0.001244477,0.0004241785,0.000001245735,0.000003948673,0.000008935373,0.0001492728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04681193,"threshold_uncertainty_score":0.3770675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07610582945069332,"score_gpt":0.3641251878865568,"score_spread":0.2880193584358635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}