{"id":"W2141920998","doi":"10.1093/annonc/mdn031","title":"Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma","year":2008,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"U.S. Food and Drug Administration","keywords":"Medicine; Gastroenterology; Diffuse large B-cell lymphoma; Internal medicine; Vorinostat; Nausea; Adverse effect; Anemia; Tolerability; Neutropenia; Vomiting; Toxicity; Phases of clinical research; Surgery; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005994708,0.000195026,0.0005396588,0.0002085717,0.00007539973,0.000001915047,0.0003280373,0.0004050662,0.00002619826],"category_scores_gemma":[0.0003591208,0.0002002057,0.0001984693,0.0002308499,0.000320261,0.000005900606,0.0002347516,0.0001564613,0.0000142542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003538718,"about_ca_system_score_gemma":0.0005710777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431048,"about_ca_topic_score_gemma":0.0002564878,"domain_scores_codex":[0.997817,0.0003343641,0.0006655566,0.0004036708,0.0002640285,0.0005153149],"domain_scores_gemma":[0.9988534,0.00005737228,0.0002595669,0.0004988894,0.0001996807,0.0001311241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02715598,0.0300714,0.0002534007,0.00003756561,0.0000545842,0.0001670519,0.0004502989,0.000008562796,0.9215275,0.00002344716,0.01177626,0.008473945],"study_design_scores_gemma":[0.1528667,0.02238645,0.00009004671,0.00000938812,0.000007984509,0.00003018185,0.00003970231,0.00005375998,0.7757161,0.0000187021,0.04862565,0.0001553302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959806,0.0006115903,0.00002108379,0.000240111,0.0002163322,0.0003974968,0.00006826241,0.000008439228,0.002456116],"genre_scores_gemma":[0.9976669,0.0006651265,0.0002113613,0.0001695837,0.000118611,0.00003470249,0.0001086966,0.00003026076,0.0009947708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1458114,"threshold_uncertainty_score":0.816415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04978978159332966,"score_gpt":0.3682998098545144,"score_spread":0.3185100282611847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}