{"id":"W2141934750","doi":"10.1074/jbc.m410654200","title":"The Phosphoinositol 3,4-Bisphosphate-binding Protein TAPP1 Interacts with Syntrophins and Regulates Actin Cytoskeletal Organization","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Muscular Dystrophy Association","keywords":"Pleckstrin homology domain; PDZ domain; Cell biology; Membrane ruffling; Scaffold protein; Cytoskeleton; Biology; Actin cytoskeleton; Phosphatidylinositol 4,5-bisphosphate; Actin; Signal transducing adaptor protein; Phosphatidylinositol; Signal transduction; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007594944,0.0005422501,0.0002291752,0.0002719901,0.0003147628,0.0003807988,0.0002519993,0.0003749673,0.001056974],"category_scores_gemma":[0.0001362806,0.0002412572,0.0002164243,0.0002162408,0.0002365913,0.0002480903,0.0004439764,0.0004574559,0.000904299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006321787,"about_ca_system_score_gemma":0.0001915283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000877794,"about_ca_topic_score_gemma":0.001186707,"domain_scores_codex":[0.9998796,0.00001229609,0.000005706785,0.000032225,0.00003786149,0.00003225273],"domain_scores_gemma":[0.9999368,0.000009060779,0.00001748127,0.000004732968,0.000008254042,0.00002369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004985654,0.000007872487,0.0002966958,0.00002546787,0.000002853184,0.000139655,0.00001150775,0.00006360429,0.9981019,0.00008539495,0.00008375901,0.00113155],"study_design_scores_gemma":[0.00003157698,0.0001499443,0.02802511,0.00001205565,0.00002913178,0.001716815,0.00007954914,0.005170927,0.9563385,0.0002487107,0.008183834,0.00001374272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904177,0.004309522,0.002530024,0.0001821771,0.00002851929,0.00001726997,0.000435394,0.0001397863,0.001939602],"genre_scores_gemma":[0.9912026,0.002017472,0.001245402,0.00008818963,0.00001831808,0.00002990845,0.001118215,0.00003327714,0.004246707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056974,"threshold_uncertainty_score":0.004586816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004674974103230389,"score_gpt":0.2059864582314816,"score_spread":0.2013114841282512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}