{"id":"W2141953337","doi":"10.1136/annrheumdis-2013-203684","title":"The Canadian Methotrexate and Etanercept Outcome Study: a randomised trial of discontinuing versus continuing methotrexate after 6 months of etanercept and methotrexate therapy in rheumatoid arthritis","year":2013,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Amgen (Canada); Southlake Regional Health Center; Centre Hospitalier de l’Université de Montréal; St Joseph's Health Centre","funders":"Genentech; AstraZeneca; Amgen Canada; Pfizer; Amgen; Bristol-Myers Squibb; Pfizer Pharmaceuticals; Pfizer Canada; Abbott Laboratories","keywords":"Medicine; Etanercept; Methotrexate; Rheumatoid arthritis; Internal medicine; Combination therapy; Clinical endpoint; Gastroenterology; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002076624,0.00183734,0.00284787,0.0003784198,0.001108978,0.0008604591,0.001260328,0.002021891,0.007780484],"category_scores_gemma":[0.003294521,0.0005613458,0.00215258,0.0006096119,0.00134983,0.000621929,0.0004818572,0.002258379,0.0004970064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006245223,"about_ca_system_score_gemma":0.0103667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2105592,"about_ca_topic_score_gemma":0.3711091,"domain_scores_codex":[0.9982219,0.0008464017,0.00009021434,0.0002332422,0.0003316976,0.0002766103],"domain_scores_gemma":[0.9982855,0.0002740183,0.000436132,0.00008064724,0.0001922703,0.0007313861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9833518,0.001582513,0.002096355,0.0005177727,0.001406115,0.00004680473,0.00004875656,0.0001966963,0.0006823587,0.0001896042,0.001097245,0.008784119],"study_design_scores_gemma":[0.9609357,0.01796152,0.01688045,0.00008315077,0.001551674,0.00004868451,0.00003723633,0.0003822142,0.0001270402,0.0001309477,0.001826559,0.00003483671],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728272,0.01138294,0.0003340037,0.001534645,0.0006253708,0.003950298,0.003194815,0.00006902917,0.00608159],"genre_scores_gemma":[0.9824564,0.004234894,0.001418921,0.001286408,0.0006329639,0.002717531,0.002190125,0.00001221621,0.005050449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2105592,"threshold_uncertainty_score":0.4186672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04059478235058027,"score_gpt":0.3312845091368322,"score_spread":0.2906897267862519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}