{"id":"W2142004059","doi":"10.1074/jbc.m512109200","title":"Intracellular HIV-Tat Expression Induces IL-10 Synthesis by the CREB-1 Transcription Factor through Ser<sup>133</sup>Phosphorylation and Its Regulation by the ERK1/2 MAPK in Human Monocytic Cells","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"","keywords":"CREB; Phosphorylation; Intracellular; MAPK/ERK pathway; Transcription factor; Cell biology; Human immunodeficiency virus (HIV); Chemistry; Molecular biology; Transcription (linguistics); Biology; Virology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203678,0.0003180602,0.0002017038,0.0002144826,0.0002415375,0.0003376961,0.0001178943,0.0001775178,0.001965413],"category_scores_gemma":[0.0001300623,0.0002257125,0.0002720293,0.0001753539,0.0002584944,0.0001955943,0.0001875501,0.0006707953,0.0006226758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003472678,"about_ca_system_score_gemma":0.0002896769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293114,"about_ca_topic_score_gemma":0.001700729,"domain_scores_codex":[0.9998621,0.00002179865,0.000009404122,0.00001343794,0.00002238314,0.00007087486],"domain_scores_gemma":[0.9999071,0.00002661412,0.000015543,0.00001844896,0.00001144987,0.00002090722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000570491,0.00006671096,0.0002815539,0.00003723641,0.000003693869,0.0001101927,0.00003872565,0.000063132,0.9973958,0.0001938341,0.00009929085,0.001139431],"study_design_scores_gemma":[0.00008983817,0.0004111548,0.01393493,0.00001449606,0.00001694857,0.0003302496,0.0001257611,0.001092962,0.981293,0.0002330538,0.002449293,0.00000829441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948699,0.001476727,0.000999614,0.0002004642,0.0000621062,0.00002300067,0.0004945089,0.00005047431,0.001823157],"genre_scores_gemma":[0.9949583,0.0006779039,0.001000351,0.00005624206,0.00002698096,0.0000263606,0.0008095871,0.0000123794,0.002431954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965413,"threshold_uncertainty_score":0.006574929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222036282597247,"score_gpt":0.242618444409886,"score_spread":0.2203980815839135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}