{"id":"W2142006091","doi":"10.1002/ddr.10050","title":"Syntheses, calcium channel agonist‐antagonist modulation effects, and nitric oxide release studies of [3‐(Benzenesulfonyl)furoxan‐4‐yloxy]alkyl 1,4‐Dihydro‐2,6‐dimethyl‐5‐nitro‐4‐(2‐trifluoromethylphenyl, benzofurazan‐4‐yl, 2‐, 3‐, or 4‐pyridyl)‐3‐pyridinecarboxylates","year":2002,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Substituent; Stereochemistry; Isopropyl; Furoxan; Agonist; Calcium channel; Calcium; Nitric oxide; Medicinal chemistry; Receptor; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844998,0.0004816775,0.0004470929,0.0002066978,0.0002688502,0.0001689376,0.000321596,0.0002094786,0.001347528],"category_scores_gemma":[0.0002740771,0.0002806283,0.0003376194,0.0002114914,0.0002055279,0.0001769021,0.0001488718,0.0003298262,0.0005429977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733407,"about_ca_system_score_gemma":0.0006194701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056103,"about_ca_topic_score_gemma":0.002139144,"domain_scores_codex":[0.9997975,0.00003656052,0.00002319721,0.00003289469,0.00005464781,0.00005510269],"domain_scores_gemma":[0.9998086,0.0000317714,0.00006001148,0.00002734826,0.00002577215,0.00004646026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011122,0.00003251943,0.00004630926,0.00004597351,0.000005859084,0.00006848008,0.00002112499,0.0002020756,0.9981047,0.00007378071,0.00002652483,0.001271452],"study_design_scores_gemma":[0.00009916521,0.0009939107,0.001451596,0.000007906369,0.00002041688,0.0001378249,0.00001285967,0.0003191347,0.9941739,0.00002122661,0.002751306,0.00001062626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898734,0.001698757,0.004789963,0.00007118416,0.00004848416,0.000273308,0.000737177,0.00007527342,0.002432512],"genre_scores_gemma":[0.9806978,0.002666226,0.01034863,0.00006663342,0.00003511328,0.0003903556,0.001209544,0.00003823754,0.00454761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347528,"threshold_uncertainty_score":0.004507959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.184692971358023,"score_gpt":0.3651271743141584,"score_spread":0.1804342029561354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}