{"id":"W2142006091","doi":"10.1002/ddr.10050","title":"Syntheses, calcium channel agonist‐antagonist modulation effects, and nitric oxide release studies of [3‐(Benzenesulfonyl)furoxan‐4‐yloxy]alkyl 1,4‐Dihydro‐2,6‐dimethyl‐5‐nitro‐4‐(2‐trifluoromethylphenyl, benzofurazan‐4‐yl, 2‐, 3‐, or 4‐pyridyl)‐3‐pyridinecarboxylates","year":2002,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Substituent; Stereochemistry; Isopropyl; Furoxan; Agonist; Calcium channel; Calcium; Nitric oxide; Medicinal chemistry; Receptor; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004283078,0.0007848651,0.001272126,0.0008268718,0.0011182,0.0002041429,0.0007703071,0.0004309485,0.000921461],"category_scores_gemma":[0.00847599,0.0005816557,0.0002131035,0.001589004,0.000864309,0.0003218524,0.0007102852,0.0008927078,0.0001905309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005863602,"about_ca_system_score_gemma":0.000277131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000312327,"about_ca_topic_score_gemma":0.00003117975,"domain_scores_codex":[0.9926347,0.0008094442,0.001509902,0.001432978,0.00218383,0.001429218],"domain_scores_gemma":[0.9909778,0.006163744,0.0004801313,0.000825986,0.001094504,0.0004578948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008489848,0.001311796,0.004413018,0.003342241,0.001043726,0.0001546446,0.002024031,0.0001371375,0.8256211,0.0001976791,0.003773302,0.1571324],"study_design_scores_gemma":[0.001623014,0.0001676304,0.01613077,0.001021549,0.0001535341,0.00003399327,0.001799938,0.009249265,0.9603822,0.0008560394,0.007391806,0.001190213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834722,0.01265255,0.00004715318,0.0008829283,0.0001228946,0.000835806,0.00005173316,0.0001955675,0.001739117],"genre_scores_gemma":[0.98977,0.00492705,0.001731555,0.00006230286,0.0002449282,0.0004645455,0.0001391456,0.00009615954,0.002564348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1559422,"threshold_uncertainty_score":0.9999918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.184692971358023,"score_gpt":0.3651271743141584,"score_spread":0.1804342029561354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}