{"id":"W2142045184","doi":"10.1089/104303401450924","title":"Retrovector Encoding a Green Fluorescent Protein–Herpes Simplex Virus Thymidine Kinase Fusion Protein Serves as a Versatile Suicide/Reporter for Cell and Gene Therapy Applications","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Medical Research Council; Cancer Research Society","keywords":"Green fluorescent protein; Thymidine kinase; Molecular biology; Biology; Suicide gene; Fusion protein; Virology; Fusion gene; Herpes simplex virus; Genetic enhancement; Viral vector; Reporter gene; Cell culture; Gene; Virus; Gene expression; Recombinant DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005509636,0.0009916235,0.0008124762,0.0006287996,0.0003482251,0.0007516719,0.0008457417,0.000771674,0.001959371],"category_scores_gemma":[0.00020691,0.00045434,0.000553517,0.0006500061,0.0004920313,0.0005080865,0.0005460201,0.001501594,0.001913044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004932327,"about_ca_system_score_gemma":0.0004279608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004743614,"about_ca_topic_score_gemma":0.0006743351,"domain_scores_codex":[0.9994195,0.0000925627,0.00006629588,0.0001365871,0.0002123582,0.00007282678],"domain_scores_gemma":[0.9998202,0.00003137387,0.00005393259,0.00003584564,0.00002557227,0.00003302916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009467088,0.00007087465,0.0002215645,0.0001432168,0.00001266303,0.0001350798,0.00004909096,0.0001655127,0.9902236,0.001187439,0.0004807039,0.007215663],"study_design_scores_gemma":[0.00005158759,0.0004501308,0.001208155,0.00002830954,0.00006749679,0.00103402,0.00004675919,0.003079191,0.9540823,0.000341014,0.03958792,0.0000231132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5726837,0.007803924,0.3876481,0.0005741719,0.0009385385,0.002058442,0.00890996,0.00475725,0.01462587],"genre_scores_gemma":[0.7247308,0.00617248,0.199148,0.0003455878,0.0001014951,0.001253664,0.02129754,0.0005994323,0.04635106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001959371,"threshold_uncertainty_score":0.006554782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03869368082242539,"score_gpt":0.3150690783921561,"score_spread":0.2763753975697307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}