{"id":"W2142087742","doi":"10.1093/nar/gkp1160","title":"The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health; Campbell Family Institute for Breast Cancer Research; Wellcome Trust","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Biology; DNA; Telomerase RNA component; Mutant; Molecular biology; Telomere-binding protein; Cell biology; In vitro; Reverse transcriptase; Biochemistry; RNA; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001336256,0.0001605924,0.0003367678,0.0002193028,0.0005186857,0.00007996923,0.0001457166,0.0001360723,0.00002142886],"category_scores_gemma":[0.000384992,0.0001183564,0.00006528068,0.0003762291,0.0004933393,0.0001647833,0.00007201068,0.0002472519,0.000003130931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007576512,"about_ca_system_score_gemma":0.0001193663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000614623,"about_ca_topic_score_gemma":0.00002004212,"domain_scores_codex":[0.9980732,0.0001466257,0.0002862505,0.0003894503,0.0005820891,0.0005223606],"domain_scores_gemma":[0.9986408,0.0003761626,0.00008596994,0.0004096252,0.0002688428,0.0002185455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001199502,0.0001511667,0.009265632,0.0001999412,0.00005197538,0.00008480305,0.002225953,4.43812e-8,0.8968522,0.0009083314,0.0008572479,0.08820318],"study_design_scores_gemma":[0.008136356,0.004217132,0.1737428,0.0005778223,0.0001206419,0.000250464,0.003856355,0.002213008,0.7856998,0.003667499,0.01695584,0.0005622788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952569,0.000498876,0.0002714897,0.002463885,0.00004112986,0.0009878175,0.00002617553,0.0000272028,0.0004265266],"genre_scores_gemma":[0.9980101,0.0004847655,0.0004062703,0.0001315421,0.00009538858,0.00002778031,0.00001291176,0.00002359603,0.0008076471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1644772,"threshold_uncertainty_score":0.4826432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04900627612196524,"score_gpt":0.355497625546267,"score_spread":0.3064913494243017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}