{"id":"W2142087742","doi":"10.1093/nar/gkp1160","title":"The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health; Campbell Family Institute for Breast Cancer Research; Wellcome Trust","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Biology; DNA; Telomerase RNA component; Mutant; Molecular biology; Telomere-binding protein; Cell biology; In vitro; Reverse transcriptase; Biochemistry; RNA; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008592114,0.000231548,0.0002099023,0.0001154041,0.0001680742,0.0002320257,0.0001597813,0.0002655739,0.001216413],"category_scores_gemma":[0.0002097617,0.0001054984,0.0001987474,0.0001232901,0.000173737,0.000194004,0.0001677253,0.0003180305,0.0009660868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404323,"about_ca_system_score_gemma":0.0002838214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004965594,"about_ca_topic_score_gemma":0.0006009915,"domain_scores_codex":[0.9999179,0.00001124814,0.00001072735,0.00001466059,0.00003187795,0.00001371171],"domain_scores_gemma":[0.9998308,0.00002308371,0.00005045077,0.00002432595,0.00002151462,0.00004969442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004892742,0.00001165888,0.0002321748,0.00001749576,0.000002386034,0.0001294494,0.000006527402,0.00004237611,0.9980414,0.0001120332,0.00002694291,0.001328559],"study_design_scores_gemma":[0.00002161976,0.0001106247,0.01398045,0.00001228743,0.0000173609,0.00177862,0.00002870122,0.0009951983,0.9735841,0.0001699885,0.009293455,0.000007555272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912925,0.001700101,0.004583892,0.0001264034,0.00002695464,0.00002202024,0.000556531,0.00007415026,0.001617398],"genre_scores_gemma":[0.9897914,0.0007386916,0.004585287,0.00004663606,0.00001396606,0.00001678048,0.001912027,0.00002402758,0.002871076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216413,"threshold_uncertainty_score":0.004069328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04900627612196524,"score_gpt":0.355497625546267,"score_spread":0.3064913494243017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}