{"id":"W2142138762","doi":"10.1074/jbc.m212855200","title":"A Ligand-induced Conformational Change in Apolipoprotein(a) Enhances Covalent Lp(a) Formation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Covalent bond; Chemistry; Conformational change; Apolipoprotein B; Biophysics; Lipoprotein; Ligand (biochemistry); Lipoprotein(a); Stereochemistry; Crystallography; Biochemistry; Cholesterol; Receptor; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466093,0.0001891876,0.0001764458,0.00006166271,0.0000933849,0.0002211202,0.0002025726,0.0002356096,0.0007220884],"category_scores_gemma":[0.0002537431,0.0001105172,0.0001333378,0.00006294602,0.0002277458,0.0001535513,0.0001361683,0.0003482741,0.0001564012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301367,"about_ca_system_score_gemma":0.0001283163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472589,"about_ca_topic_score_gemma":0.0003279602,"domain_scores_codex":[0.9999006,0.00002471448,0.000006777505,0.00002385486,0.0000247543,0.00001928589],"domain_scores_gemma":[0.9998667,0.00005289639,0.00003400713,0.00001117128,0.000012989,0.00002218532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005614032,0.00002432742,0.00008232827,0.00001464417,0.000002271789,0.00002120815,0.000009273544,0.00007834241,0.9991255,0.00005649216,0.000008737382,0.000520797],"study_design_scores_gemma":[0.00001437481,0.0002966423,0.001263057,0.000001768697,0.000004485702,0.00007178306,0.000008199137,0.00132244,0.9966758,0.00002391264,0.0003131488,0.000004318228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983955,0.0002042307,0.001067835,0.00003643728,0.000005261055,0.000007620694,0.00002103491,0.00002307148,0.0002389571],"genre_scores_gemma":[0.9984616,0.00008906487,0.0010678,0.00003904836,0.000003584863,0.000008278874,0.00002670466,0.000003362,0.0003005292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007220884,"threshold_uncertainty_score":0.002415597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05606254714884237,"score_gpt":0.302762970904108,"score_spread":0.2467004237552657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}