{"id":"W2142194813","doi":"10.1016/j.cell.2011.10.046","title":"Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Canada Research Chairs; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Research Resources; Canadian Institutes of Health Research; Terry Fox Foundation; Human Frontier Science Program; National Institutes of Health; European Molecular Biology Organization; U.S. Department of Energy","keywords":"Ankyrin repeat; Cherubism; Biology; Peptide sequence; Genetics; Ankyrin; Computational biology; Polymerase; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004478784,0.000472342,0.0006930715,0.0003063871,0.0007546199,0.001014633,0.0009968014,0.001243926,0.002959923],"category_scores_gemma":[0.0006838483,0.0002669083,0.0006650868,0.0001883891,0.0009529106,0.001542151,0.0004939017,0.002112062,0.001854913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006384678,"about_ca_system_score_gemma":0.0004542603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00029869,"about_ca_topic_score_gemma":0.0002688922,"domain_scores_codex":[0.9998504,0.00001940105,0.00001347371,0.00004217637,0.00003757112,0.00003693471],"domain_scores_gemma":[0.9998221,0.00005216902,0.00003716555,0.0000375869,0.00002646295,0.00002451141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007229131,0.0001445536,0.002575709,0.0002966191,0.00008032923,0.003021962,0.0002936245,0.01431409,0.7995154,0.1569111,0.003637803,0.01848577],"study_design_scores_gemma":[0.0002841108,0.0007134655,0.003289848,0.00006323339,0.0001387127,0.00588759,0.0004040707,0.07559296,0.6629199,0.2105457,0.04000117,0.0001592507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7957592,0.005735249,0.169934,0.008005018,0.000995842,0.0001426159,0.0008108878,0.001229473,0.0173877],"genre_scores_gemma":[0.9784025,0.001442197,0.01627849,0.0006239364,0.0000928923,0.00004647697,0.0003677214,0.00008409216,0.002661731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002959923,"threshold_uncertainty_score":0.009902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1007135040464307,"score_gpt":0.2988541061465599,"score_spread":0.1981406021001292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}