{"id":"W2142215232","doi":"10.1126/science.1209202","title":"The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans","year":2011,"lang":"en","type":"article","venue":"Science","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":560,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; National Center for Research Resources; Wellcome Trust","keywords":"Biology; Introgression; Genotyping; Allele; Human leukocyte antigen; Evolutionary biology; Balancing selection; Haplotype; Genetics; Genome; Natural selection; Human genome; Selection (genetic algorithm); Gene; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0005275849,0.0001408987,0.0001958311,0.00007702039,0.0009982942,0.00001785384,0.0009375031,0.0001069057,0.00005457208],"category_scores_gemma":[0.00002253621,0.00008234708,0.00004444991,0.0002133991,0.003901032,0.0001161783,0.0001563024,0.0002695785,0.00005409418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002638587,"about_ca_system_score_gemma":0.0001204628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003145076,"about_ca_topic_score_gemma":0.00005068399,"domain_scores_codex":[0.9987381,0.00008965193,0.0002561053,0.0003239384,0.00008051618,0.0005117244],"domain_scores_gemma":[0.9991688,0.00005977574,0.0001818095,0.0004412559,0.0001259253,0.00002239086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004992701,0.00007488102,0.0007831908,0.00000788053,0.00003357361,0.0000015198,0.001428298,0.000002519818,0.9912218,0.005637411,0.0001343222,0.0006246443],"study_design_scores_gemma":[0.001433392,0.0008073716,0.006794656,0.0001274277,0.00003374497,0.0001517773,0.001506964,0.00007136545,0.9760135,0.001181899,0.01150567,0.0003722277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789752,0.01734497,0.0003865584,0.00006463491,0.0005466423,0.0002241615,0.00001070534,0.00004881895,0.002398289],"genre_scores_gemma":[0.9959604,0.00004955678,0.00003386873,0.00002334566,0.000009267535,0.00001817259,0.000008564318,0.000008798058,0.003888015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01729541,"threshold_uncertainty_score":0.9988098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03157365167974861,"score_gpt":0.2374623420947025,"score_spread":0.2058886904149539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}