{"id":"W2142215232","doi":"10.1126/science.1209202","title":"The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans","year":2011,"lang":"en","type":"article","venue":"Science","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":560,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; National Center for Research Resources; Wellcome Trust","keywords":"Biology; Introgression; Genotyping; Allele; Human leukocyte antigen; Evolutionary biology; Balancing selection; Haplotype; Genetics; Genome; Natural selection; Human genome; Selection (genetic algorithm); Gene; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004497157,0.0001426605,0.0002440447,0.0005759416,0.0003566934,0.0005689098,0.0001451788,0.000247256,0.0008164206],"category_scores_gemma":[0.0005755835,0.0001330121,0.0001340766,0.0006104914,0.0007312563,0.0003123504,0.0005256983,0.0003888417,0.00009942171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801834,"about_ca_system_score_gemma":0.0001003174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008493242,"about_ca_topic_score_gemma":0.001600834,"domain_scores_codex":[0.9997681,0.00007025804,0.00001249796,0.00008639604,0.00003075104,0.00003205614],"domain_scores_gemma":[0.9998103,0.00005742675,0.00006023571,0.00003317051,0.00001869768,0.00002026284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007511402,0.00006512211,0.6687455,0.0001495297,0.0005410002,0.00115367,0.004124315,0.001048358,0.2530901,0.002618589,0.0001963614,0.0675164],"study_design_scores_gemma":[0.00001270016,0.00008537839,0.9921018,0.00001721333,0.00008952555,0.00109112,0.0006239275,0.0003332952,0.003038735,0.001108304,0.001483322,0.0000146447],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985933,0.0004236056,0.0003976538,0.00003631852,0.000002309359,0.000002150708,0.00002493777,0.000003085181,0.0005166107],"genre_scores_gemma":[0.9990916,0.0003703277,0.0003116504,0.00003555738,0.000006304674,0.000002237644,0.00003591225,0.000002355381,0.0001441337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008493242,"threshold_uncertainty_score":0.002731264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03157365167974861,"score_gpt":0.2374623420947025,"score_spread":0.2058886904149539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}