{"id":"W2142253810","doi":"10.1093/nar/gkp086","title":"Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Canadian Institutes of Health Research; National Science Foundation","keywords":"Biology; Hox gene; Histone; Genetics; Bromodomain; Histone H3; Gene; Methylation; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009629325,0.0001146525,0.0001196393,0.00009807208,0.0001846772,0.00002985168,0.0002542116,0.0001771673,0.0001195032],"category_scores_gemma":[0.0001479786,0.00009440665,0.00007735955,0.0003692169,0.0002199284,0.000009489982,0.00005875,0.0002483798,0.00004232533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008497071,"about_ca_system_score_gemma":0.00008344143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004651807,"about_ca_topic_score_gemma":0.00001530751,"domain_scores_codex":[0.9982789,0.0003005925,0.0002773417,0.0003541671,0.0004960629,0.0002929911],"domain_scores_gemma":[0.9988587,0.00003078607,0.00009349841,0.0005208296,0.0004360549,0.00006005229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001822264,0.00004611637,0.00002690125,0.000007763592,0.00001564901,5.989028e-7,0.00007363257,0.00004172215,0.8388223,0.00003342543,0.018729,0.1420206],"study_design_scores_gemma":[0.0004384162,0.0005127492,0.001960169,0.00002921236,0.000005293187,0.000007142763,0.00006758617,0.0001716832,0.8912948,0.001744056,0.1036318,0.0001370348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906255,0.0030672,0.0008173997,0.001675978,0.0000646956,0.0006679152,0.00003062188,0.00001728287,0.003033423],"genre_scores_gemma":[0.9954612,0.0005059068,0.0002985321,0.00003186128,0.0001706921,0.00004151192,0.0002169536,0.0000222487,0.003251079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1418836,"threshold_uncertainty_score":0.3849791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736159255097107,"score_gpt":0.3181694094834771,"score_spread":0.280807816932506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}