{"id":"W2142253810","doi":"10.1093/nar/gkp086","title":"Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Canadian Institutes of Health Research; National Science Foundation","keywords":"Biology; Hox gene; Histone; Genetics; Bromodomain; Histone H3; Gene; Methylation; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009689766,0.0001494198,0.0001143553,0.0000844292,0.0001466468,0.0002522401,0.0001399561,0.0001520359,0.0006729292],"category_scores_gemma":[0.0001592281,0.00009986382,0.0001473192,0.00007383913,0.0001713288,0.0001109137,0.0001966844,0.0002118631,0.0003288121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002898888,"about_ca_system_score_gemma":0.0001192413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029635,"about_ca_topic_score_gemma":0.001267164,"domain_scores_codex":[0.99993,0.00001105026,0.000002532269,0.00001600614,0.00002221502,0.00001828269],"domain_scores_gemma":[0.9999456,0.000009422504,0.00001364145,0.000006219828,0.000006925412,0.00001821845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006163235,0.000002733321,0.0004931911,0.000007044258,0.000001769057,0.00002730275,0.00001260785,0.00003794937,0.9987695,0.00003224597,0.00002318832,0.0005308396],"study_design_scores_gemma":[0.00001696952,0.00006147662,0.01562292,0.00000218139,0.000005649867,0.0004180493,0.00003609608,0.002590343,0.9796777,0.00005799124,0.001504429,0.00000628445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981907,0.0002655272,0.0009887102,0.00003187048,0.00000229576,0.000002542908,0.00004470174,0.00002586536,0.0004478324],"genre_scores_gemma":[0.9982384,0.00007575865,0.0006476123,0.00002197964,0.000002323695,0.000004555583,0.0002065419,0.00001354103,0.0007891833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029635,"threshold_uncertainty_score":0.002251208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736159255097107,"score_gpt":0.3181694094834771,"score_spread":0.280807816932506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}