{"id":"W2142282509","doi":"10.1093/toxsci/kfm189","title":"microRNAs in Adult Rodent Liver Are Refractory to Dioxin Treatment","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Downregulation and upregulation; microRNA; Transactivation; Transcriptome; Aryl hydrocarbon receptor; Biology; miR-155; Gene expression; In vivo; Endocrinology; Internal medicine; Chemistry; Molecular biology; Gene; Transcription factor; Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203033,0.0004446935,0.0003838784,0.0005923499,0.0001857447,0.0003111929,0.0002035063,0.000288928,0.00335193],"category_scores_gemma":[0.0002249438,0.0003559765,0.0004417342,0.0001963543,0.0003085595,0.0002126597,0.0002364481,0.0007415076,0.00151661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557235,"about_ca_system_score_gemma":0.0002182924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004182198,"about_ca_topic_score_gemma":0.0009899376,"domain_scores_codex":[0.9996091,0.00003666507,0.00003928961,0.0001518641,0.00008958206,0.00007354006],"domain_scores_gemma":[0.9996325,0.00003166243,0.0001306253,0.00005737833,0.00005424861,0.00009359339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001743331,0.00001781864,0.0004684344,0.00002376913,0.000007781197,0.00006498412,0.00001111874,0.0000139856,0.9980349,0.0000400681,0.00006646835,0.001076511],"study_design_scores_gemma":[0.00003279484,0.0008012296,0.02281262,0.000009316824,0.00003544298,0.00085867,0.00007561897,0.0002089608,0.969126,0.00009342283,0.005933214,0.00001255554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816727,0.004306315,0.005838391,0.0002876877,0.0001668028,0.0001083544,0.002489287,0.0005618194,0.004568589],"genre_scores_gemma":[0.9756677,0.001502611,0.004019056,0.0004161667,0.00003130685,0.0002510123,0.003709414,0.000196783,0.01420605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335193,"threshold_uncertainty_score":0.0112133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02732613929777145,"score_gpt":0.2995857145741467,"score_spread":0.2722595752763753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}