{"id":"W2142327734","doi":"10.1093/nar/gkl1153","title":"2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity","year":2007,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oligonucleotide; RNase P; RNase H; Biology; RNA; Circular dichroism; Duplex (building); DNA; Small interfering RNA; Stereochemistry; Molecular biology; Biochemistry; Biophysics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001971776,0.0002025573,0.000193321,0.0002571184,0.0002843798,0.0001058762,0.0006148745,0.0002938605,0.0001487108],"category_scores_gemma":[0.0004040585,0.0001942651,0.0001195931,0.0003463923,0.0002054908,0.00002325078,0.0004036824,0.0004459916,0.0006879325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007703016,"about_ca_system_score_gemma":0.000192276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000961375,"about_ca_topic_score_gemma":0.00007214109,"domain_scores_codex":[0.9976109,0.00009936136,0.0003101829,0.0004847446,0.0006857273,0.0008091118],"domain_scores_gemma":[0.9983575,0.00007819301,0.00005469191,0.0005892163,0.0005842946,0.0003360886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006225632,0.000102919,0.001394372,0.00002061542,0.00005352943,0.000008075394,0.0002720529,0.00003189652,0.9621775,0.0003219851,0.009940678,0.02505387],"study_design_scores_gemma":[0.00087866,0.001232233,0.08352403,0.0000452748,0.000008724622,0.00002525891,0.0006856096,0.0003018887,0.8495262,0.000294457,0.06299727,0.0004803437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733512,0.00007442234,0.003073839,0.0006339986,0.0001538462,0.000374588,0.00001980498,0.00003118409,0.02228707],"genre_scores_gemma":[0.9956627,0.00006766357,0.0006189679,0.000567422,0.0004782031,0.00002821106,0.00005040034,0.00003190783,0.002494483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1126512,"threshold_uncertainty_score":0.884221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05534021576203661,"score_gpt":0.3593488403886335,"score_spread":0.3040086246265968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}