{"id":"W2142327734","doi":"10.1093/nar/gkl1153","title":"2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity","year":2007,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oligonucleotide; RNase P; RNase H; Biology; RNA; Circular dichroism; Duplex (building); DNA; Small interfering RNA; Stereochemistry; Molecular biology; Biochemistry; Biophysics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164415,0.0005512325,0.0003490955,0.0001590351,0.0001432927,0.000300303,0.0003739977,0.0004222414,0.001218073],"category_scores_gemma":[0.0002276102,0.0002514844,0.0002275956,0.0001480495,0.0002552514,0.0002182818,0.0001665057,0.0005166437,0.0005729702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302679,"about_ca_system_score_gemma":0.0001489734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002193285,"about_ca_topic_score_gemma":0.0003607181,"domain_scores_codex":[0.9997793,0.00005275524,0.00002088506,0.00006576657,0.00004683583,0.00003447765],"domain_scores_gemma":[0.999856,0.00003728678,0.00005041086,0.00001584547,0.00001637597,0.00002408393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003719805,0.000009289264,0.00002269802,0.00002362369,0.000002313807,0.00002147012,0.000008630625,0.0000571692,0.9987894,0.00009904562,0.00001989077,0.0009095051],"study_design_scores_gemma":[0.000006353491,0.00009461778,0.0001629014,0.000001544059,0.00000465876,0.00006404272,0.000003182842,0.0002536112,0.9975482,0.00002039275,0.001837074,0.000003553535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576635,0.003227484,0.03210478,0.0001615888,0.0001517309,0.0001957594,0.0004758411,0.000773532,0.005245925],"genre_scores_gemma":[0.9624134,0.0016552,0.03004084,0.0001300276,0.00003241264,0.0003324397,0.000550087,0.00009213905,0.004753381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218073,"threshold_uncertainty_score":0.004074872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05534021576203661,"score_gpt":0.3593488403886335,"score_spread":0.3040086246265968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}