{"id":"W2142335982","doi":"10.1371/journal.pone.0027808","title":"Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Robarts Clinical Trials; Western University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care","keywords":"Warfarin; Pharmacodynamics; VKORC1; CYP2C9; Dosing; Medicine; Pharmacokinetics; Pharmacogenetics; Pharmacology; Internal medicine; Vitamin K epoxide reductase; Atrial fibrillation; Renal function; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152457,0.000236626,0.0005616203,0.000334876,0.0001827982,0.0005214198,0.0002105134,0.0003952845,0.0006788688],"category_scores_gemma":[0.005901958,0.0002226241,0.0006036093,0.0004992482,0.0002333607,0.0002248687,0.0001753372,0.000684762,0.0002175901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004838188,"about_ca_system_score_gemma":0.0004450622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002222174,"about_ca_topic_score_gemma":0.001771834,"domain_scores_codex":[0.9991546,0.0003309336,0.00008490354,0.0001665954,0.0001721137,0.00009084711],"domain_scores_gemma":[0.9962178,0.00217615,0.0009705711,0.0003033042,0.0001260286,0.0002061293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004083396,0.0000366452,0.9921665,0.000008144267,0.00008137951,0.0001465653,0.00006417996,0.001406706,0.0008092039,0.00007365381,0.00006805592,0.00473064],"study_design_scores_gemma":[0.00002291472,0.0003908119,0.9878203,0.000004831155,0.00006888044,0.000685415,0.0000593242,0.009893201,0.0006364819,0.0002105473,0.0001975624,0.000009664692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989473,0.0001327377,0.0005506045,0.00003479186,0.000001716664,0.000007041684,0.0001160767,0.000008153538,0.0002017019],"genre_scores_gemma":[0.9994619,0.00003838088,0.0002716518,0.000009863957,0.000002551147,0.000005232577,0.0001517837,0.000003114898,0.00005554477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222174,"threshold_uncertainty_score":0.006094813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3086663071683788,"score_gpt":0.4322649969106029,"score_spread":0.1235986897422242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}