{"id":"W2142335982","doi":"10.1371/journal.pone.0027808","title":"Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Robarts Clinical Trials; Western University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care","keywords":"Warfarin; Pharmacodynamics; VKORC1; CYP2C9; Dosing; Medicine; Pharmacokinetics; Pharmacogenetics; Pharmacology; Internal medicine; Vitamin K epoxide reductase; Atrial fibrillation; Renal function; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003038675,0.0002818141,0.0005374309,0.0001373079,0.0001372445,0.00001019007,0.0001545373,0.0002183405,0.000339915],"category_scores_gemma":[0.0000397798,0.0002765926,0.00007157626,0.000116405,0.0003816922,0.00008607632,0.000151045,0.0003333797,0.00001352242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000200959,"about_ca_system_score_gemma":0.00004435886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002313459,"about_ca_topic_score_gemma":0.000008555588,"domain_scores_codex":[0.9979807,0.0003384238,0.0007267762,0.0004058463,0.0001725967,0.0003756621],"domain_scores_gemma":[0.9989319,0.0001487875,0.0002679868,0.0001765606,0.0001127579,0.0003620077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005318036,0.003307345,0.638983,0.0002445639,0.0006649392,0.00007389058,0.001074502,0.000007470118,0.2852592,0.00002786014,0.000005317831,0.06982006],"study_design_scores_gemma":[0.005846973,0.0003344101,0.345282,0.00003632773,0.002002842,0.00003060719,0.00002920963,0.01843585,0.6270261,0.0002231411,0.000422708,0.0003298342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952839,0.002814156,0.00001457052,0.00003161687,0.000275542,0.0005177408,0.00009951451,0.00004616093,0.0009168125],"genre_scores_gemma":[0.9616013,0.03391871,0.003814021,0.0002211152,0.0002205203,0.00004655133,0.000006190599,0.00003745164,0.0001341072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3417669,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3086663071683788,"score_gpt":0.4322649969106029,"score_spread":0.1235986897422242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}