{"id":"W2142336102","doi":"10.4049/jimmunol.1401357","title":"An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Epitope; Viral quasispecies; Biology; T-cell receptor; Hypervariable region; Virology; Human leukocyte antigen; Genetics; Antigen; Hepatitis C virus; Virus; T cell; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205527,0.0001438022,0.000103327,0.00008728798,0.0001000968,0.0002012909,0.0001025345,0.0001707599,0.001163907],"category_scores_gemma":[0.0001502817,0.00009468618,0.000107453,0.00006162786,0.0001821325,0.0001523353,0.0001870568,0.0002853533,0.0002657119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009815236,"about_ca_system_score_gemma":0.00007826275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001502247,"about_ca_topic_score_gemma":0.0002568671,"domain_scores_codex":[0.9998964,0.00002360402,0.000005502655,0.00002172581,0.00002438918,0.00002830814],"domain_scores_gemma":[0.9999049,0.00003008891,0.00002060445,0.00001439807,0.00001140675,0.00001855167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004542932,0.000005972537,0.000430854,0.000007349261,0.000001936497,0.00004308749,0.000009002407,0.00007710342,0.9987141,0.00008486773,0.000007797737,0.0005724782],"study_design_scores_gemma":[0.00002767354,0.0005708794,0.03382294,0.0000126742,0.00002772662,0.002370924,0.0001197336,0.004331632,0.9555906,0.0005735514,0.002540171,0.0000114908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973693,0.0002010647,0.001606567,0.00001685439,0.000003541984,0.000002966005,0.00001988474,0.0000158574,0.0007638723],"genre_scores_gemma":[0.9994647,0.00005372392,0.0003152241,0.00001738419,0.000001969229,0.000001388098,0.00002146569,0.000003307968,0.0001208082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163907,"threshold_uncertainty_score":0.003893614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228590599525799,"score_gpt":0.2996684943802945,"score_spread":0.2768094344277146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}