{"id":"W2142368962","doi":"10.4049/jimmunol.177.8.5059","title":"Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Institute for Research in Immunology and Cancer; Université de Montréal","funders":"","keywords":"Biology; Cullin; Neddylation; Transcription factor; Kinase; Ubiquitin; Cell biology; Innate immune system; TANK-binding kinase 1; NEDD8; Phosphorylation; Sendai virus; Ubiquitin ligase; IRF1; Virus; MAP kinase kinase kinase; Virology; Protein kinase A; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717271,0.0002954558,0.0002246135,0.0001815275,0.000198209,0.0004018435,0.000172196,0.0003448688,0.0006165962],"category_scores_gemma":[0.000159467,0.0001129105,0.0004622549,0.00009269183,0.0002055969,0.0003229158,0.0001908521,0.0003055248,0.0002253632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045313,"about_ca_system_score_gemma":0.0002355374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004182485,"about_ca_topic_score_gemma":0.0003634366,"domain_scores_codex":[0.9998622,0.00001660267,0.00002030392,0.00003101241,0.0000314398,0.00003847895],"domain_scores_gemma":[0.9998773,0.00001267106,0.00005013071,0.00001631983,0.00001417977,0.0000293329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000303356,0.00002447635,0.001488002,0.00007092099,0.00001256003,0.0001625624,0.00001898358,0.0001291402,0.9958568,0.0001939565,0.00002701159,0.0017122],"study_design_scores_gemma":[0.00001680585,0.0001133347,0.02349062,0.00000900952,0.00002407155,0.0007416148,0.00004459664,0.001271853,0.9727955,0.0001659769,0.001316696,0.000009898758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99323,0.004483135,0.001411082,0.00007357927,0.00001572981,0.000008850307,0.0002268983,0.00002292484,0.0005278272],"genre_scores_gemma":[0.99747,0.0008438547,0.0007334866,0.00002432777,0.0000037936,0.00000941396,0.0001790557,0.000004043754,0.0007321066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006165962,"threshold_uncertainty_score":0.003287673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184677200276153,"score_gpt":0.2250913872001541,"score_spread":0.2132446151973926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}