{"id":"W2142395647","doi":"10.1371/journal.pone.0003247","title":"MHC Class I Endosomal and Lysosomal Trafficking Coincides with Exogenous Antigen Loading in Dendritic Cells","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of California Berkeley","keywords":"Endosome; Antigen processing; Endocytic cycle; MHC class I; Cell biology; Cross-presentation; Internalization; MHC restriction; Biology; Antigen; Antigen presentation; MHC class II; Major histocompatibility complex; Transporter associated with antigen processing; Cytotoxic T cell; Endocytosis; T cell; Intracellular; Immune system; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233495,0.0001817592,0.0002206175,0.0002238693,0.0002095478,0.0005381774,0.0001829009,0.000373185,0.001173395],"category_scores_gemma":[0.0001543768,0.0001305765,0.000223424,0.0002002253,0.0002209088,0.0002360917,0.0003367555,0.0005600986,0.000990901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007826206,"about_ca_system_score_gemma":0.0003621629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000513276,"about_ca_topic_score_gemma":0.0003654682,"domain_scores_codex":[0.9998214,0.00001451175,0.00001515427,0.00003824285,0.00005067978,0.00006009076],"domain_scores_gemma":[0.9998492,0.0000229471,0.00003245644,0.00002127145,0.00003971007,0.00003446404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002247805,0.00001775275,0.0008363978,0.00004991942,0.000004096819,0.0001634553,0.00003549787,0.00005253214,0.9972235,0.0003158708,0.00005625115,0.00101991],"study_design_scores_gemma":[0.00001708266,0.00009102113,0.0108204,0.00001032974,0.00001204823,0.0007194036,0.00008717054,0.0008986283,0.9840147,0.0001129641,0.003210823,0.000005309051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878417,0.001951059,0.005606353,0.0000850283,0.00004046608,0.00003994203,0.0007520479,0.0001038166,0.003579554],"genre_scores_gemma":[0.9937859,0.0006974211,0.002466488,0.00005983623,0.00001387456,0.00004524439,0.0009191927,0.00003389173,0.001978167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173395,"threshold_uncertainty_score":0.005678356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822781976900977,"score_gpt":0.2016748860986524,"score_spread":0.1734470663296426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}