{"id":"W2142395647","doi":"10.1371/journal.pone.0003247","title":"MHC Class I Endosomal and Lysosomal Trafficking Coincides with Exogenous Antigen Loading in Dendritic Cells","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of California Berkeley","keywords":"Endosome; Antigen processing; Endocytic cycle; MHC class I; Cell biology; Cross-presentation; Internalization; MHC restriction; Biology; Antigen; Antigen presentation; MHC class II; Major histocompatibility complex; Transporter associated with antigen processing; Cytotoxic T cell; Endocytosis; T cell; Intracellular; Immune system; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134877,0.0002237372,0.0004338828,0.0001955956,0.000327917,0.00001756157,0.0001586511,0.0001904409,0.00015121],"category_scores_gemma":[0.00003388675,0.0002027151,0.00004316109,0.0001624808,0.0003864951,0.0001522256,0.00004342714,0.0003297402,0.0001087496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004351578,"about_ca_system_score_gemma":0.00008984077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008845547,"about_ca_topic_score_gemma":0.00004053127,"domain_scores_codex":[0.9985961,0.0002247026,0.0002910373,0.0003065729,0.00006379864,0.0005177448],"domain_scores_gemma":[0.9993755,0.0002571929,0.00008248751,0.0002210482,0.00004172664,0.00002202352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008857066,0.0008133862,0.02216362,0.00003731094,0.0004155941,0.0001961068,0.002399008,0.000004230659,0.9724854,0.00003856728,0.00001192485,0.000549194],"study_design_scores_gemma":[0.002617192,0.0005877448,0.03357966,0.0002818301,0.00006065732,0.0007554896,0.0003539649,0.00001185826,0.9610819,0.000006059713,0.000369208,0.0002944482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839981,0.01512384,0.00001951845,0.00006572742,0.00006409204,0.0002858221,0.000008546466,0.0000814492,0.0003528596],"genre_scores_gemma":[0.9971818,0.001332384,0.0003220323,0.0001177906,0.00002153325,0.00002206798,0.00001450892,0.00003451757,0.0009533257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01379145,"threshold_uncertainty_score":0.826648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822781976900977,"score_gpt":0.2016748860986524,"score_spread":0.1734470663296426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}