{"id":"W2142439096","doi":"10.1182/blood-2003-01-0292","title":"Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Vector (molecular biology); Factor IX; Clotting factor; Viral vector; Adeno-associated virus; Duchenne muscular dystrophy; Gene expression; Phenotype; Gene; Medicine; Expression cassette; Biology; Immunology; Virology; Internal medicine; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387722,0.0001210986,0.0001416827,0.00005276992,0.00007078187,0.00001118561,0.000117945,0.0001315542,0.00005561435],"category_scores_gemma":[0.000185163,0.0001272879,0.00005974304,0.0001647269,0.00005046123,0.000004011154,0.0000335641,0.00008660145,0.000002002443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003125614,"about_ca_system_score_gemma":0.00022989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009707414,"about_ca_topic_score_gemma":0.0003687997,"domain_scores_codex":[0.9989762,0.0001881319,0.0001653866,0.0002457903,0.0001532005,0.0002712396],"domain_scores_gemma":[0.9993882,0.000007393844,0.00008087367,0.0002805269,0.0001638953,0.00007915439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003914757,0.0005319487,0.001621183,0.000008737532,0.00009900715,0.000003518127,0.00004693707,0.000279222,0.9966581,0.00001421191,0.00004398931,0.000301663],"study_design_scores_gemma":[0.002003376,0.002763934,0.0006938321,0.000007854751,0.00004324282,0.000009165873,0.00008735893,0.0003662923,0.9937361,0.00004585233,0.00009454542,0.0001484415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998879,0.000353448,0.00007527819,0.000009795026,0.0001268296,0.000169145,0.00001374223,0.0000139047,0.0003588342],"genre_scores_gemma":[0.9991499,0.00001634147,0.0001138315,0.00003804741,0.00009638409,0.000006817392,0.00006918018,0.00002978897,0.0004796614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002922003,"threshold_uncertainty_score":0.5190649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485165318450932,"score_gpt":0.2761301485472401,"score_spread":0.2612784953627307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}