{"id":"W2142439096","doi":"10.1182/blood-2003-01-0292","title":"Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Vector (molecular biology); Factor IX; Clotting factor; Viral vector; Adeno-associated virus; Duchenne muscular dystrophy; Gene expression; Phenotype; Gene; Medicine; Expression cassette; Biology; Immunology; Virology; Internal medicine; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830939,0.0002244463,0.0002006362,0.0002163006,0.0001423151,0.0003356622,0.0001784415,0.000289195,0.0009389968],"category_scores_gemma":[0.0001788082,0.0001059415,0.0001756141,0.0001241428,0.0002737415,0.0002622803,0.0001750934,0.0006100115,0.0004190776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076571,"about_ca_system_score_gemma":0.0002618558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006709625,"about_ca_topic_score_gemma":0.0007433001,"domain_scores_codex":[0.9998691,0.00002115611,0.00001355971,0.00002692594,0.00004607244,0.00002306723],"domain_scores_gemma":[0.9998876,0.00001672826,0.00002797294,0.00001886258,0.00001558401,0.00003317997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004967276,0.0000359409,0.00007843389,0.00002200959,0.000003221222,0.00006289648,0.00001467215,0.00008406555,0.9969552,0.0003021632,0.000107124,0.002284661],"study_design_scores_gemma":[0.00004654369,0.0009346411,0.00223507,0.000007343382,0.00001954869,0.0009215875,0.00002484587,0.00211238,0.9831563,0.0001615945,0.01037197,0.000008258922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740311,0.002098729,0.01910822,0.000326708,0.0001213101,0.0001105617,0.0003337529,0.0005286129,0.003341021],"genre_scores_gemma":[0.9829429,0.001264753,0.008683262,0.00005375813,0.00002663894,0.00006579848,0.0007384553,0.00007619789,0.006148193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009389968,"threshold_uncertainty_score":0.003141284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485165318450932,"score_gpt":0.2761301485472401,"score_spread":0.2612784953627307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}