{"id":"W2142450574","doi":"10.1182/blood-2008-09-179796","title":"Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Proteasome; Bortezomib; Proteasome inhibitor; Cancer research; Chemistry; Transcription factor; Multiple myeloma; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009892682,0.0005306517,0.0003364481,0.0002555511,0.000108302,0.0002880531,0.0001430553,0.0001953777,0.001221825],"category_scores_gemma":[0.00009574394,0.000127293,0.0002158265,0.0002580002,0.0001524603,0.0001825482,0.0001515037,0.0003863114,0.000442512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218731,"about_ca_system_score_gemma":0.0002530389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002532172,"about_ca_topic_score_gemma":0.0009657977,"domain_scores_codex":[0.9999553,0.000004567873,0.000004234009,0.000008723821,0.00001405058,0.00001303131],"domain_scores_gemma":[0.9999063,0.00001336642,0.0000257812,0.00001162033,0.00001415473,0.00002882268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002135547,0.00007447747,0.0002965445,0.00005430202,0.00001554377,0.00008622474,0.000007940052,0.000422245,0.9941194,0.00005331021,0.00006688965,0.004589544],"study_design_scores_gemma":[0.0000659963,0.001376853,0.002507831,0.000006267206,0.00004373352,0.0005368111,0.00001517957,0.0005385919,0.9912277,0.00004659914,0.003628767,0.000005618048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824207,0.005174036,0.007658228,0.0001265868,0.00002694624,0.0001968227,0.001194888,0.0001852814,0.003016494],"genre_scores_gemma":[0.9856679,0.003243269,0.005897251,0.00008940915,0.00001195301,0.00008659338,0.001725057,0.00003131231,0.003247249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221825,"threshold_uncertainty_score":0.004087448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009213873991936529,"score_gpt":0.2406993930551196,"score_spread":0.2314855190631831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}