{"id":"W2142465751","doi":"10.1046/j.1462-5822.2001.00119.x","title":"Cholera toxin and Escherichia coli enterotoxin B-subunits inhibit macrophage-mediated antigen processing and presentation: evidence for antigen persistence in non-acidic recycling endosomal compartments","year":2001,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Medical Research Council; University of Bristol","keywords":"Endosome; Biology; Internalization; Antigen; Antigen presentation; Endocytic cycle; Antigen processing; Cholera toxin; Vacuole; Lysosome; Cell biology; Phagolysosome; Microbiology; Endocytosis; Phagocytosis; Receptor; Intracellular; Immune system; T cell; Phagosome; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143927,0.0002436906,0.0002782524,0.0001257765,0.00009286319,0.0002492549,0.0002636319,0.0004346456,0.00081444],"category_scores_gemma":[0.0002045514,0.0001686415,0.0002519092,0.0001244372,0.0002576325,0.0002434695,0.000260656,0.0003469201,0.0002875507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048205,"about_ca_system_score_gemma":0.0002785287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625015,"about_ca_topic_score_gemma":0.0005292731,"domain_scores_codex":[0.9998133,0.00004049824,0.0000145165,0.00001578128,0.0000335252,0.00008243492],"domain_scores_gemma":[0.9998347,0.00005320015,0.00002572395,0.00001927477,0.00002276939,0.00004438761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006318221,0.0001023773,0.0002209532,0.00004620464,0.000007845082,0.00007265156,0.0000165666,0.00003554989,0.9978291,0.00005485194,0.0000184705,0.0009635073],"study_design_scores_gemma":[0.0001572548,0.003230965,0.01521088,0.00001182451,0.00003694485,0.0005260608,0.00005927306,0.0008541033,0.9781466,0.00009024325,0.001669054,0.000006737974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964632,0.002277136,0.0004851397,0.00005142891,0.00001272157,0.00001411779,0.00004153369,0.00001050626,0.000644151],"genre_scores_gemma":[0.996458,0.001073056,0.0004162836,0.00004805962,0.00001049167,0.00003199388,0.0001603878,0.000008238592,0.001793475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00081444,"threshold_uncertainty_score":0.002724588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04496091512955572,"score_gpt":0.3058966240476834,"score_spread":0.2609357089181277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}