{"id":"W2142517633","doi":"10.1161/circresaha.114.303784","title":"Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy","year":2014,"lang":"en","type":"article","venue":"Circulation Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; York University","keywords":"Heart failure; Pressure overload; Muscle hypertrophy; Calcineurin; Fibrosis; Pathological; microRNA; Internal medicine; Myocyte; Cardiac function curve; Medicine; Ventricular remodeling; Biology; Endocrinology; Cardiac hypertrophy; Transplantation; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009117267,0.00008769597,0.0001261892,0.00004942499,0.0001431244,0.00002950748,0.0002086969,0.0001522746,0.00004001333],"category_scores_gemma":[0.0004724752,0.00006584077,0.0001098999,0.000169765,0.0002707095,0.000003956882,0.0001274121,0.000149634,0.00003873543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002026039,"about_ca_system_score_gemma":0.00006432956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005346488,"about_ca_topic_score_gemma":0.000003527435,"domain_scores_codex":[0.9982216,0.0006984274,0.000186099,0.0003128432,0.0003561372,0.0002248336],"domain_scores_gemma":[0.9989188,0.00008680759,0.0000534535,0.000566287,0.0003096896,0.00006490529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004686926,0.00003301825,0.02214869,0.00001225886,0.00001947596,6.109207e-7,0.00002861718,0.0003301283,0.9755103,0.0001371983,0.0007532436,0.0009795964],"study_design_scores_gemma":[0.0003204255,0.0001045465,0.6801328,0.00001738384,0.000009464036,0.000004271227,0.00002898414,0.0007366263,0.3030233,0.001267457,0.01423166,0.0001231234],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967337,0.0005508796,0.001328832,0.0004735833,0.00006254733,0.0004664556,0.0000232542,0.000008766362,0.0003519405],"genre_scores_gemma":[0.9991012,0.00001556249,0.0002493827,0.00005383456,0.0003285641,0.00005460769,0.000134986,0.00001537637,0.00004655377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.672487,"threshold_uncertainty_score":0.2684909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03414558453477693,"score_gpt":0.3122377647528497,"score_spread":0.2780921802180727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}