{"id":"W2142551442","doi":"10.1096/fj.03-0648fje","title":"Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M <sub>2</sub> or M <sub>3</sub> muscarinic acetylcholine receptors","year":2004,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Muscarinic acetylcholine receptor; Bronchoconstriction; Methacholine; Bradycardia; Medicine; Acetylcholine; Internal medicine; Endocrinology; Muscarinic acetylcholine receptor M3; Vagus nerve; Agonist; In vivo; Heart rate; Stimulation; Receptor; Lung; Asthma; Biology; Respiratory disease; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000860232,0.0002199852,0.0002813912,0.0001261732,0.0001599005,0.00005296216,0.000225584,0.00022274,0.00001639686],"category_scores_gemma":[0.0001820356,0.0001617856,0.0001432418,0.0002554017,0.0001215006,0.00002090082,0.00009894868,0.000430772,0.000004897091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006354209,"about_ca_system_score_gemma":0.0002282957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001738749,"about_ca_topic_score_gemma":0.00007682947,"domain_scores_codex":[0.9984362,0.0001789236,0.0005120764,0.0002737922,0.0002508583,0.0003481805],"domain_scores_gemma":[0.9991634,0.00005494515,0.0003226178,0.0001906021,0.00012667,0.0001417778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002169095,0.00004907018,0.0008806913,0.00001414023,0.00008435572,0.00001500472,0.0002073337,0.001163075,0.9898221,0.00001649861,0.00005577801,0.007475076],"study_design_scores_gemma":[0.001845928,0.0002727712,0.0007597132,0.0001030339,0.00004231736,0.0003888271,0.0003039372,0.00005165075,0.9957853,0.0001338882,0.0001188093,0.0001938385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995769,0.0008733239,0.002504557,0.0001398145,0.0004572402,0.0001857053,0.00001322608,0.000009945975,0.00004716363],"genre_scores_gemma":[0.9946705,0.00442327,0.000289666,0.0001312326,0.0004107086,0.000005617876,0.00002996669,0.00003180376,0.000007248293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007281237,"threshold_uncertainty_score":0.6597424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009835929669962483,"score_gpt":0.2244194735658197,"score_spread":0.2145835438958572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}