{"id":"W2142553006","doi":"10.1155/2014/379748","title":"Evaluation of Azathioprine-Induced Cytotoxicity in an<i>In Vitro</i>Rat Hepatocyte System","year":2014,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Cytotoxicity; Reactive oxygen species; Chemistry; Glutathione; Hepatocyte; Xanthine oxidase; Pharmacology; Trolox; Oxidative stress; Superoxide dismutase; Catalase; Biochemistry; Mesna; Antioxidant; Hepatoprotection; In vitro; Biology; Cisplatin; Medicine; Enzyme; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000543175,0.0007714528,0.000566826,0.0003344405,0.0002466328,0.000286737,0.0004162769,0.0004328072,0.001096328],"category_scores_gemma":[0.0001881229,0.0001793651,0.0005549264,0.0004037397,0.0002280548,0.0002713385,0.0002327012,0.0004937506,0.000569312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272742,"about_ca_system_score_gemma":0.0001789472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006454819,"about_ca_topic_score_gemma":0.0006880534,"domain_scores_codex":[0.9995602,0.0001553488,0.00006620387,0.0000639289,0.0001011833,0.00005309079],"domain_scores_gemma":[0.9996536,0.00007833121,0.00007674548,0.00006085902,0.00009313875,0.00003735018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002117535,0.00008046943,0.0002035992,0.0001188554,0.00001778526,0.00008864571,0.00002753863,0.0001210134,0.9979671,0.00004043842,0.00002597648,0.001096939],"study_design_scores_gemma":[0.00001278938,0.001526882,0.001380104,0.000005195086,0.00004891405,0.0001524593,0.00001933551,0.0005115076,0.995822,0.00001790008,0.0004976953,0.000005272008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753971,0.00603045,0.01360476,0.0001056414,0.0001184769,0.0001539357,0.0007721718,0.0002652693,0.003552204],"genre_scores_gemma":[0.977427,0.005266003,0.0119959,0.0001061076,0.00006217301,0.0002206664,0.001663834,0.00004596244,0.00321227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096328,"threshold_uncertainty_score":0.003667593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1336871135120594,"score_gpt":0.4252181134204796,"score_spread":0.2915309999084202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}