{"id":"W2142553006","doi":"10.1155/2014/379748","title":"Evaluation of Azathioprine-Induced Cytotoxicity in an<i>In Vitro</i>Rat Hepatocyte System","year":2014,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Cytotoxicity; Reactive oxygen species; Chemistry; Glutathione; Hepatocyte; Xanthine oxidase; Pharmacology; Trolox; Oxidative stress; Superoxide dismutase; Catalase; Biochemistry; Mesna; Antioxidant; Hepatoprotection; In vitro; Biology; Cisplatin; Medicine; Enzyme; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01053733,0.0001467491,0.0003085766,0.001545174,0.00003936098,0.00003483718,0.0003209486,0.0001937507,0.0001152659],"category_scores_gemma":[0.00161842,0.0001442692,0.00006650248,0.0009487066,0.0001103391,0.0002270307,0.00008255657,0.000473793,0.00004933812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002145192,"about_ca_system_score_gemma":0.0005053632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420543,"about_ca_topic_score_gemma":0.0002485948,"domain_scores_codex":[0.9942156,0.00100267,0.0006004596,0.0004413163,0.003370038,0.00036993],"domain_scores_gemma":[0.9973705,0.0001966229,0.0001338698,0.0004168364,0.001717593,0.0001645584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004349481,0.0004152026,0.006082645,0.00007969252,0.00002885486,0.00001018273,0.0003310106,0.00001721699,0.9829752,0.0004283946,0.00004028854,0.009156378],"study_design_scores_gemma":[0.00389698,0.0002024991,0.04108538,0.0002421689,0.000009837755,0.00001927165,0.000212215,0.1127054,0.8412015,0.0002458361,0.00007888045,0.000100043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947908,0.00002036698,0.0001067752,0.001092423,0.0003770709,0.001017035,0.00001246288,0.00004003802,0.002543007],"genre_scores_gemma":[0.9986609,0.000006166449,0.0005719265,0.00004753393,0.0003943357,0.0001197245,0.0001090572,0.00003011531,0.0000602614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1417737,"threshold_uncertainty_score":0.5883129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1336871135120594,"score_gpt":0.4252181134204796,"score_spread":0.2915309999084202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}