{"id":"W2142562240","doi":"10.1016/j.molcel.2012.01.027","title":"Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of New Brunswick; Canada Research Chairs; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Dynein; Microtubule; Biology; Cell biology; Cytoskeleton; Dynactin; Dynein ATPase; Actin; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000496906,0.0004099981,0.0003937157,0.0002354342,0.0003862419,0.0007969076,0.0007004648,0.0004592282,0.001447645],"category_scores_gemma":[0.0003300945,0.0002416773,0.0002981838,0.0001125285,0.0005886262,0.0006936673,0.0003670307,0.0009344046,0.0002352311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006016188,"about_ca_system_score_gemma":0.0004182391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000328746,"about_ca_topic_score_gemma":0.0005176535,"domain_scores_codex":[0.9998354,0.00002967935,0.00001046232,0.00002588773,0.00004673231,0.0000518676],"domain_scores_gemma":[0.9998368,0.00006583933,0.00004450733,0.00002132022,0.0000139548,0.00001756121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003361306,0.00007264125,0.0003448242,0.0001355914,0.00002692485,0.000511352,0.00003880638,0.003006397,0.9650415,0.02502365,0.0002726348,0.005189446],"study_design_scores_gemma":[0.000105078,0.0001809476,0.002762775,0.00002033218,0.0000617314,0.000740602,0.00008097217,0.02987958,0.9531088,0.006213544,0.006815553,0.00003001767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457765,0.004377727,0.03235681,0.002404187,0.0001793605,0.00006069407,0.000259146,0.0004206857,0.01416489],"genre_scores_gemma":[0.9961619,0.001290579,0.001577707,0.00007591824,0.00001698683,0.00001620977,0.00003910054,0.00001264026,0.0008089725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447645,"threshold_uncertainty_score":0.004842877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006040476553653042,"score_gpt":0.2191715003868517,"score_spread":0.2131310238331987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}