{"id":"W2142567184","doi":"10.1085/jgp.116.5.679","title":"μ-Conotoxin Giiia Interactions with the Voltage-Gated Na+ Channel Predict a Clockwise Arrangement of the Domains","year":2000,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Chemistry; KcsA potassium channel; Biophysics; Ion channel; Clockwise; Stereochemistry; Neurotoxin; Crystallography; Biochemistry; Biology; Receptor; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007572229,0.0002387795,0.0001426969,0.0001192851,0.00009562878,0.0001890053,0.0001845606,0.0001865282,0.0004402463],"category_scores_gemma":[0.0001474739,0.0001064929,0.0001760589,0.000126404,0.0001992973,0.0001226085,0.0001421023,0.0003690029,0.0001554739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500007,"about_ca_system_score_gemma":0.0001039728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007102273,"about_ca_topic_score_gemma":0.0008051966,"domain_scores_codex":[0.9999084,0.00001242496,0.000004594348,0.00002123351,0.00003206321,0.00002115642],"domain_scores_gemma":[0.9998858,0.00001789096,0.00005484745,0.000008485744,0.00001069914,0.00002225046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006539359,0.00001307405,0.004160016,0.00001344981,0.000009323985,0.00005268673,0.00001212399,0.0002483821,0.9943263,0.00006227106,0.00001363456,0.001023276],"study_design_scores_gemma":[0.00002014035,0.0007456279,0.114858,0.00001657837,0.00004657868,0.0008894285,0.00007490814,0.00730303,0.8738012,0.0002092635,0.002025498,0.000009763135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985384,0.0002648098,0.0007672602,0.00002063715,0.000003057806,0.000005411679,0.00003543998,0.000009985033,0.0003550601],"genre_scores_gemma":[0.9982262,0.0001693109,0.001113191,0.00002745509,0.000001406201,0.000004862383,0.0001788125,0.000003115091,0.000275562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007102273,"threshold_uncertainty_score":0.002539456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007675290895920911,"score_gpt":0.2224461325893305,"score_spread":0.2147708416934095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}