{"id":"W2142583671","doi":"10.1128/mcb.02038-07","title":"Evidence for a Superoxide Permeability Pathway in Endosomal Membranes","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Endosome; NADPH oxidase; Cell biology; Superoxide; DIDS; Biology; Biochemistry; Biophysics; Chemistry; Reactive oxygen species; Intracellular; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003062403,0.0002439036,0.0004074925,0.0001170672,0.0001772724,0.00000598338,0.0001948005,0.0003073591,0.0001272994],"category_scores_gemma":[0.0001750194,0.000209412,0.0001336353,0.0001125009,0.0004261638,0.0000670567,0.0001034962,0.0002097467,0.00004290933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002449336,"about_ca_system_score_gemma":0.00006894665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009398553,"about_ca_topic_score_gemma":0.00002492634,"domain_scores_codex":[0.998187,0.0003956367,0.0003120655,0.0005975488,0.00002429815,0.0004834635],"domain_scores_gemma":[0.9993218,0.0002291195,0.00005447516,0.0002986245,0.00005815947,0.00003781089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00021548,0.00008525685,0.003517295,0.00003803763,0.0000408254,0.00008179731,0.0002380529,0.000001400699,0.9895293,0.004886195,0.00001182746,0.00135453],"study_design_scores_gemma":[0.001442165,0.0004613299,0.0009805122,0.00002799477,0.00001444041,0.0001519613,0.00007532066,0.000004897514,0.9904962,0.00157487,0.004529382,0.0002409453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787696,0.01567405,0.004413492,0.0002573157,0.0002092208,0.0004982704,0.00003185002,0.00003888938,0.0001073347],"genre_scores_gemma":[0.9985498,0.0002968558,0.0002937554,0.0003444961,0.00002298814,0.0001349076,0.0001096672,0.00001932143,0.0002282412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01978019,"threshold_uncertainty_score":0.8539574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03999368019349084,"score_gpt":0.2542285618347568,"score_spread":0.2142348816412659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}