{"id":"W2142642125","doi":"10.1016/s0140-6736(08)60208-1","title":"LDL-cholesterol concentrations: a genome-wide association study","year":2008,"lang":"en","type":"review","venue":"The Lancet","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":357,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; European Commission; British Heart Foundation; Wellcome Trust; GlaxoSmithKline","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Linkage disequilibrium; Genetic association; SNP; Biology; Genetics; Cholesterol; Locus (genetics); Gene; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006668806,0.0002766505,0.001153531,0.00002953197,0.0002109955,0.00003395537,0.0005271056,0.0003630944,0.00001668803],"category_scores_gemma":[0.0009630087,0.0001899154,0.0002733905,0.00009839251,0.00004021185,0.000001811008,0.0001345848,0.0002880722,0.0001120071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001128852,"about_ca_system_score_gemma":0.0001918802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002088254,"about_ca_topic_score_gemma":0.00007895565,"domain_scores_codex":[0.9976865,0.0008593756,0.0005211872,0.0003837144,0.0001539648,0.0003952237],"domain_scores_gemma":[0.9982237,0.0002557871,0.0006026429,0.0007878352,0.0000832544,0.00004681477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003572286,0.0006957435,0.2325162,0.001047226,0.004435114,0.0000128114,0.000905105,0.000106575,0.00001679547,0.00003236658,0.54973,0.2104663],"study_design_scores_gemma":[0.0003581112,0.0001124005,0.01530168,0.00007650362,0.0002401575,0.000007558642,0.00003817891,0.000001098786,3.098382e-7,0.00001609622,0.9836546,0.0001933024],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001869727,0.9951794,0.0001072121,0.0004973052,0.0002338179,0.001082161,0.0001084983,0.00002020711,0.0009016825],"genre_scores_gemma":[0.001229765,0.9931753,0.00009006859,0.0009159378,0.001708318,0.0002775206,0.0005660281,0.00003446524,0.002002632],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4339246,"threshold_uncertainty_score":0.7744526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05377665245659304,"score_gpt":0.3343379319283683,"score_spread":0.2805612794717753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}