{"id":"W2142648718","doi":"10.1016/j.mce.2005.10.023","title":"3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research; Shionogi","keywords":"Steroid; Chemistry; Potency; Gene isoform; Receptor; Selectivity; Dehydrogenase; Inhibitory postsynaptic potential; Hydroxysteroid dehydrogenase; Biochemistry; Enzyme; Biology; In vitro; Endocrinology; Hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001666021,0.0003320732,0.0006314153,0.0002921181,0.0001345,0.00003203158,0.00003975258,0.0001996949,0.000007521266],"category_scores_gemma":[0.00007034384,0.0002800658,0.0000534646,0.000139925,0.0002455027,0.0001929205,0.00009382864,0.0002797151,9.92323e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004780512,"about_ca_system_score_gemma":0.00008109395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007289812,"about_ca_topic_score_gemma":0.00003876646,"domain_scores_codex":[0.9984024,0.0001331731,0.0003777408,0.0005228003,0.0001875068,0.0003763665],"domain_scores_gemma":[0.9993451,0.0001140578,0.0001407065,0.0001457544,0.00009270872,0.0001617373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009392471,0.0002638064,0.003958175,0.0002220556,0.00005667387,0.00004623348,0.0007558112,0.000006297357,0.9808805,0.0001094729,0.00005321131,0.01270849],"study_design_scores_gemma":[0.002924007,0.00230889,0.0009223751,0.00009400256,0.00007725177,0.0001674463,0.0004676439,0.0005625515,0.9907628,0.00007836628,0.001377888,0.0002568015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928257,0.005358092,0.0001873944,0.0005938922,0.00009062365,0.000788055,0.00002705474,0.00002539307,0.0001037275],"genre_scores_gemma":[0.9980708,0.0009230164,0.0003707031,0.0002383125,0.00006657707,0.00003357203,0.00005066202,0.00003415038,0.00021225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01245169,"threshold_uncertainty_score":0.9999651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227623751935799,"score_gpt":0.2506951219647864,"score_spread":0.2384188844454284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}