{"id":"W2142648718","doi":"10.1016/j.mce.2005.10.023","title":"3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research; Shionogi","keywords":"Steroid; Chemistry; Potency; Gene isoform; Receptor; Selectivity; Dehydrogenase; Inhibitory postsynaptic potential; Hydroxysteroid dehydrogenase; Biochemistry; Enzyme; Biology; In vitro; Endocrinology; Hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126426,0.00051656,0.0006250291,0.0004615216,0.0002029053,0.0003302698,0.0003571497,0.0002381513,0.001737563],"category_scores_gemma":[0.000221144,0.0002791274,0.0003952512,0.0004671477,0.0002308749,0.0002063609,0.0001613098,0.0006216805,0.0006995388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553356,"about_ca_system_score_gemma":0.0003702805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490684,"about_ca_topic_score_gemma":0.004492735,"domain_scores_codex":[0.9997341,0.00007420484,0.00002737597,0.00002185914,0.00005912245,0.00008334024],"domain_scores_gemma":[0.9997903,0.00007005106,0.00004268013,0.00002854452,0.0000267545,0.00004180603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00125505,0.0002020184,0.0006379466,0.0001536721,0.00005167306,0.000206239,0.0001234929,0.0003831494,0.9843885,0.0003589437,0.0002195116,0.01201988],"study_design_scores_gemma":[0.0001317471,0.001634806,0.004004201,0.000008606366,0.00009524359,0.0004965474,0.00004019344,0.0003987489,0.9860407,0.00004922767,0.007088705,0.00001139939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589566,0.03008403,0.004163708,0.0001426267,0.0001512921,0.0001048721,0.0008401989,0.0002537423,0.005302987],"genre_scores_gemma":[0.9643052,0.02346217,0.00275659,0.0001017364,0.00007867396,0.00007756704,0.002054642,0.00005685294,0.007106628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737563,"threshold_uncertainty_score":0.005812705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227623751935799,"score_gpt":0.2506951219647864,"score_spread":0.2384188844454284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}