{"id":"W2142696637","doi":"10.1093/molbev/msp028","title":"Molecular Evolution of the    Lens Crystallin Superfamily: Evidence for a Retained Ancestral Function in  N Crystallins?","year":2009,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome Canada; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Crystallin; Nonsynonymous substitution; Phylogenetic tree; Molecular evolution; Genetics; Sister group; Evolutionary biology; Negative selection; Functional divergence; Phylogenetics; Lineage (genetic); Gene duplication; Synonymous substitution; Gene; Clade; Gene family; Codon usage bias; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430857,0.0001735827,0.0002400981,0.0003455361,0.0002876807,0.0004232756,0.0002552046,0.0003345943,0.0007794463],"category_scores_gemma":[0.0004380679,0.0001030536,0.0001521753,0.0003801843,0.0005161975,0.0004839535,0.0003204522,0.0003228659,0.0003147871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004571098,"about_ca_system_score_gemma":0.0003673363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002309942,"about_ca_topic_score_gemma":0.002743876,"domain_scores_codex":[0.9998739,0.00001929539,0.000007577022,0.00005161409,0.00002552409,0.00002208106],"domain_scores_gemma":[0.9997756,0.00005514464,0.00006717541,0.00002700641,0.00003616977,0.00003888841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009018181,0.00005717959,0.2740049,0.0002304353,0.0001032234,0.0009331486,0.0009031948,0.001629743,0.668062,0.001898093,0.0001440159,0.05113235],"study_design_scores_gemma":[0.00003635934,0.0003400172,0.9635815,0.00006298809,0.00009510754,0.001548673,0.0005991983,0.008059047,0.02058021,0.001625696,0.003438184,0.00003306233],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971578,0.00110521,0.0009771577,0.00008190685,0.000003007579,0.000002884411,0.00004510631,0.00001097298,0.0006160262],"genre_scores_gemma":[0.9979879,0.0007250876,0.0008449928,0.00006470007,0.00001019991,0.00000242447,0.0000904654,0.000005547208,0.0002686169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309942,"threshold_uncertainty_score":0.004592955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831676926258402,"score_gpt":0.2785365681797989,"score_spread":0.2602197989172149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}