{"id":"W2142713036","doi":"10.1172/jci39395","title":"The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Elsa U. Pardee Foundation; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Deutsche Krebshilfe; National Heart, Lung, and Blood Institute; Emerald Foundation; Memorial Sloan-Kettering Cancer Center; Deutsche Forschungsgemeinschaft; Commonwealth Foundation; American Association for Cancer Research","keywords":"Cytolysis; Fas ligand; Host (biology); Ligand (biochemistry); Immunology; Graft-versus-host disease; Virology; Biology; Disease; Chemistry; Medicine; Cell biology; Pathology; Cytotoxicity; Apoptosis; Biochemistry; Genetics; In vitro; Receptor; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001244488,0.0001380128,0.0003597897,0.00006060389,0.000299297,0.00004585504,0.0001971028,0.0001672504,0.000006874027],"category_scores_gemma":[0.003429664,0.00008819094,0.0002453639,0.00007661456,0.0005303491,0.0001904266,0.00001523989,0.0003388681,0.000007931005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001601112,"about_ca_system_score_gemma":0.0001785465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001959556,"about_ca_topic_score_gemma":0.00000360677,"domain_scores_codex":[0.9982547,0.0003188867,0.00102581,0.0001413815,0.00005922385,0.0001999923],"domain_scores_gemma":[0.9967229,0.001979605,0.000861914,0.0001791495,0.0001866335,0.00006975724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06459977,0.0005638743,0.008319704,0.00006430913,0.001166164,0.00003427384,0.0006848188,0.00002464722,0.8037404,0.006409026,0.01285845,0.1015345],"study_design_scores_gemma":[0.02695853,0.00848902,0.7199423,0.0007265577,0.0007438359,0.0001495856,0.0009347699,0.0001462833,0.1234382,0.03481927,0.08304974,0.0006018189],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97321,0.0162622,0.0002194257,0.009085671,0.0009823298,0.0002009221,0.000008879289,0.00001288398,0.000017701],"genre_scores_gemma":[0.9955378,0.00263647,0.0001724161,0.0008536206,0.000186031,0.000004089487,0.000009253716,0.00001066048,0.0005897159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7116227,"threshold_uncertainty_score":0.4105876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06071592026586368,"score_gpt":0.3468981384378936,"score_spread":0.2861822181720299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}