{"id":"W2142713036","doi":"10.1172/jci39395","title":"The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Elsa U. Pardee Foundation; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Deutsche Krebshilfe; National Heart, Lung, and Blood Institute; Emerald Foundation; Memorial Sloan-Kettering Cancer Center; Deutsche Forschungsgemeinschaft; Commonwealth Foundation; American Association for Cancer Research","keywords":"Cytolysis; Fas ligand; Host (biology); Ligand (biochemistry); Immunology; Graft-versus-host disease; Virology; Biology; Disease; Chemistry; Medicine; Cell biology; Pathology; Cytotoxicity; Apoptosis; Biochemistry; Genetics; In vitro; Receptor; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522768,0.0003808489,0.0002504209,0.0002677033,0.0001440546,0.0005302234,0.000164462,0.0003220184,0.0009730125],"category_scores_gemma":[0.0002052117,0.0001601165,0.0001509797,0.0001145653,0.0002398119,0.0002513142,0.0002228677,0.0005498072,0.0004042315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000363502,"about_ca_system_score_gemma":0.000242663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857128,"about_ca_topic_score_gemma":0.0003471207,"domain_scores_codex":[0.9996892,0.00005606303,0.00005663362,0.00004634435,0.00009502653,0.00005684156],"domain_scores_gemma":[0.9996395,0.00003728691,0.000170866,0.00003249643,0.00002666848,0.00009311818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131788,0.00002204837,0.0004604617,0.00003469595,0.000003625376,0.00007820033,0.00001129377,0.00009318206,0.9973362,0.0001210983,0.00002083305,0.001705208],"study_design_scores_gemma":[0.0000481626,0.0006382167,0.01366028,0.00002212915,0.00003211836,0.001481524,0.00005429515,0.001364143,0.977905,0.000179178,0.00460745,0.000007399688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909112,0.004615111,0.002562547,0.000113232,0.00003023837,0.00002823003,0.0003574025,0.0001736072,0.001208469],"genre_scores_gemma":[0.9962054,0.0008560698,0.001257081,0.00003323258,0.000008515069,0.00002775945,0.0004036684,0.00001536131,0.001192944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009730125,"threshold_uncertainty_score":0.003255069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06071592026586368,"score_gpt":0.3468981384378936,"score_spread":0.2861822181720299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}