{"id":"W2142727073","doi":"10.1158/1078-0432.ccr-14-1651","title":"Bromodomain Inhibition in Diffuse Large B-cell Lymphoma—Giving MYC a Brake","year":2014,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Bromodomain; Epigenetics; Cancer research; Enhancer; Cancer; Lymphoma; Biology; Histone; Diffuse large B-cell lymphoma; Pathogenesis; Mef2; Gene; Genetics; Transcription factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007858853,0.0005653864,0.0007468282,0.000342181,0.0004758493,0.0006804367,0.0004655478,0.005910668,0.001359798],"category_scores_gemma":[0.001505609,0.0002155569,0.000680895,0.000277904,0.0006733602,0.0004092322,0.0001935316,0.003939559,0.001457274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00136702,"about_ca_system_score_gemma":0.0003393353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006261939,"about_ca_topic_score_gemma":0.001141442,"domain_scores_codex":[0.9997073,0.00008686368,0.00003187367,0.00003213046,0.00007965299,0.00006231325],"domain_scores_gemma":[0.9995475,0.0002843223,0.00002636151,0.00003456795,0.00003471119,0.00007254628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0047616,0.001189772,0.008073849,0.0008257463,0.0002088922,0.2162365,0.0001920705,0.002912333,0.04812917,0.01531853,0.462563,0.2395885],"study_design_scores_gemma":[0.006227128,0.007173942,0.02715428,0.0004514859,0.0003294,0.2231754,0.0002516706,0.01136409,0.05167946,0.03216311,0.6398568,0.0001731996],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1943895,0.04942146,0.004278437,0.6658207,0.02490029,0.0004369692,0.0007914506,0.0009261841,0.05903509],"genre_scores_gemma":[0.5857021,0.02587406,0.003196608,0.311223,0.03768203,0.0003608311,0.0004241323,0.0001345648,0.03540266],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005910668,"threshold_uncertainty_score":0.009918451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09706866988461825,"score_gpt":0.4317421091213841,"score_spread":0.3346734392367658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}