{"id":"W2142755954","doi":"10.1016/j.cell.2012.11.024","title":"Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1306,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph; Lunenfeld-Tanenbaum Research Institute; Jewish General Hospital; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Autocrine signalling; Microvesicles; Biology; Wnt signaling pathway; Cell biology; Exosome; Stromal cell; Cancer research; Cell signaling; Cancer-Associated Fibroblasts; Tumor microenvironment; Signal transduction; Cell migration; Cancer cell; Fibroblast; Cell; Cancer; Cell culture; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003579017,0.0003186654,0.0002502772,0.000346212,0.0004513029,0.001172789,0.0001725465,0.000517047,0.00167457],"category_scores_gemma":[0.0003066357,0.0001861343,0.0003356494,0.0002137463,0.0002343341,0.001100577,0.0008342826,0.0006205373,0.0005361926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005469303,"about_ca_system_score_gemma":0.0004400685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213873,"about_ca_topic_score_gemma":0.0005821637,"domain_scores_codex":[0.9997638,0.00006563091,0.00002120794,0.00002590551,0.00005115134,0.00007231431],"domain_scores_gemma":[0.9998766,0.00002600338,0.00002638785,0.00001439838,0.00002398619,0.00003264452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001269847,0.00006521912,0.002713525,0.0002676221,0.00003787701,0.001222698,0.0001898671,0.0002857096,0.9688667,0.008121815,0.0007036239,0.01625545],"study_design_scores_gemma":[0.0001667622,0.0002994509,0.01579872,0.00007416046,0.00007685924,0.002346696,0.0005786398,0.003316889,0.953257,0.001779902,0.02228463,0.00002043612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757895,0.01239137,0.005908649,0.0008047737,0.0001535718,0.00005148668,0.0003859393,0.00006533944,0.004449368],"genre_scores_gemma":[0.9921151,0.003295052,0.001157028,0.00006634637,0.00003002256,0.00002850503,0.0001963959,0.00001601256,0.00309543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167457,"threshold_uncertainty_score":0.005601943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006892650042276545,"score_gpt":0.2397605442701026,"score_spread":0.232867894227826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}