{"id":"W2142778159","doi":"10.1128/aac.00990-07","title":"Calcineurin Inhibitor Agents Interact Synergistically with Antifungal Agents In Vitro against <i>Cryptococcus neoformans</i> Isolates: Correlation with Outcome in Solid Organ Transplant Recipients with Cryptococcosis","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Toronto General Hospital; University Health Network","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Cryptococcosis; Calcineurin; Antifungal; Cryptococcus; Microbiology; Biology; In vitro; Immunology; Transplantation; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002391517,0.0004964077,0.0007164719,0.0003754035,0.0001808475,0.00006927404,0.0001019722,0.0001643468,0.00005605624],"category_scores_gemma":[0.000009669283,0.0003342229,0.00007329231,0.0005987403,0.0001710402,0.0002401633,0.00002899748,0.0004817787,0.000009791657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539834,"about_ca_system_score_gemma":0.00005618292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487073,"about_ca_topic_score_gemma":0.0004802562,"domain_scores_codex":[0.9977105,0.00003681302,0.0007087659,0.0005844443,0.0002728948,0.0006866251],"domain_scores_gemma":[0.9991906,0.00005475562,0.0001876334,0.0002466602,0.0001233711,0.0001969356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009293159,0.001274732,0.9590123,0.0001365093,0.0002332895,0.0004906887,0.001605199,0.0001433963,0.02420459,0.000003550342,0.0005465463,0.003056031],"study_design_scores_gemma":[0.01472522,0.001533623,0.9546167,0.001650622,0.0001235872,0.0001752034,0.0001962925,0.0009649784,0.02343844,0.000001490237,0.001951638,0.0006221463],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958121,0.00001385145,0.001578653,0.0004955708,0.0001633464,0.00126438,0.00003748057,0.00005602395,0.0005786098],"genre_scores_gemma":[0.9945383,0.0004177304,0.0006762162,0.003849582,0.00008819548,0.00002968051,0.0001099648,0.00007940068,0.0002109224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005432063,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578931047812744,"score_gpt":0.2797841045804546,"score_spread":0.2639947941023272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}