{"id":"W2142778159","doi":"10.1128/aac.00990-07","title":"Calcineurin Inhibitor Agents Interact Synergistically with Antifungal Agents In Vitro against <i>Cryptococcus neoformans</i> Isolates: Correlation with Outcome in Solid Organ Transplant Recipients with Cryptococcosis","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Toronto General Hospital; University Health Network","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Cryptococcosis; Calcineurin; Antifungal; Cryptococcus; Microbiology; Biology; In vitro; Immunology; Transplantation; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004536977,0.0002720841,0.0004028996,0.0004033154,0.0003016226,0.0004937074,0.0001180039,0.0002634852,0.001033316],"category_scores_gemma":[0.001320929,0.0001434666,0.0002704423,0.0003304597,0.0002393338,0.0001977636,0.0002395607,0.0003456861,0.0001511096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815054,"about_ca_system_score_gemma":0.0002936079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006528262,"about_ca_topic_score_gemma":0.001079723,"domain_scores_codex":[0.9993749,0.0001659496,0.00007722922,0.0000656671,0.0001517078,0.0001645858],"domain_scores_gemma":[0.9987122,0.0004097025,0.0004270041,0.00008051845,0.0001159822,0.0002545654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007127448,0.001039779,0.7589084,0.0001896566,0.0003394376,0.002761355,0.0002941796,0.0003516991,0.2008394,0.00008378586,0.000310687,0.02775413],"study_design_scores_gemma":[0.0002329274,0.01223389,0.8547904,0.00004157136,0.0005639216,0.01408788,0.000565952,0.0008551429,0.1147322,0.00009921075,0.00177804,0.00001886128],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985589,0.0006640002,0.0000654583,0.0000273704,0.000004088842,0.00001056495,0.00002469716,0.000002592256,0.0006423162],"genre_scores_gemma":[0.9995854,0.0001616069,0.00008738099,0.00002073984,0.000009152293,0.000004931536,0.0000476208,8.864376e-7,0.0000822285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033316,"threshold_uncertainty_score":0.003456771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578931047812744,"score_gpt":0.2797841045804546,"score_spread":0.2639947941023272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}