{"id":"W2142786659","doi":"10.1093/molehr/gag077","title":"Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases","year":2003,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"","keywords":"Heteroplasmy; Biology; Blastomere; Mitochondrial DNA; Polar body; Genetics; Embryo; Genotype; Preimplantation genetic diagnosis; Oocyte; Andrology; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172802,0.0003001324,0.0002428021,0.0009015825,0.0002403457,0.000358964,0.0004418565,0.001036766,0.003286213],"category_scores_gemma":[0.001653264,0.0002224526,0.0001645274,0.0002173562,0.0003549879,0.0003877464,0.0002075074,0.001065789,0.0007432225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532028,"about_ca_system_score_gemma":0.0003010891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001684429,"about_ca_topic_score_gemma":0.0002501725,"domain_scores_codex":[0.9998428,0.00006337749,0.00000989258,0.00001911493,0.00004392388,0.00002086656],"domain_scores_gemma":[0.9989713,0.0006298494,0.00007786408,0.0000549481,0.0001051961,0.0001608602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002570859,0.0005267221,0.07071794,0.000369514,0.00004374864,0.01605987,0.0004305164,0.001305887,0.6952326,0.00389529,0.002602104,0.2062449],"study_design_scores_gemma":[0.000368126,0.01045384,0.1814838,0.0003074939,0.0003537961,0.09549934,0.001271368,0.01076687,0.6485144,0.01197372,0.03887225,0.000134989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.884383,0.01902285,0.08016104,0.004767858,0.0003245961,0.0001838044,0.0002420243,0.0004297984,0.01048508],"genre_scores_gemma":[0.920041,0.009425145,0.06299832,0.0006076861,0.0003529464,0.0001151568,0.0005923295,0.0000425607,0.00582488],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003286213,"threshold_uncertainty_score":0.01099348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203882899452377,"score_gpt":0.2572574379673053,"score_spread":0.2452186089727815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}