{"id":"W2142786659","doi":"10.1093/molehr/gag077","title":"Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases","year":2003,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"","keywords":"Heteroplasmy; Biology; Blastomere; Mitochondrial DNA; Polar body; Genetics; Embryo; Genotype; Preimplantation genetic diagnosis; Oocyte; Andrology; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027611,0.0001459443,0.0001692258,0.0000605829,0.0001151515,0.00001699149,0.00008114262,0.0001189336,0.00005004196],"category_scores_gemma":[0.0003855392,0.0001570543,0.0001426117,0.00009304965,0.00006235794,0.000004770885,0.0000183383,0.00004346167,0.000003931594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001342262,"about_ca_system_score_gemma":0.00004295957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008567131,"about_ca_topic_score_gemma":0.00001179817,"domain_scores_codex":[0.9986631,0.0001240561,0.0002817425,0.0006251062,0.0001170877,0.0001888933],"domain_scores_gemma":[0.9990878,0.000007772856,0.0001469665,0.0005437696,0.0001597235,0.00005396575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402566,0.000131607,0.003103568,0.00005759916,0.00004361493,0.000001993101,0.00002637323,0.0002527236,0.9927573,0.001057078,0.001871594,0.0005562915],"study_design_scores_gemma":[0.0008348276,0.0006408873,0.002072857,0.000009023624,0.000079801,0.00004097785,0.000022105,0.000003091649,0.9675239,0.001317405,0.02727818,0.0001769466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687867,0.000963505,0.02765746,0.0000419337,0.001179888,0.0009492464,0.00003438142,0.00002524447,0.0003616404],"genre_scores_gemma":[0.9894599,0.00006517803,0.007526829,0.00005965167,0.0007207745,0.0005838323,0.0003934148,0.00004386029,0.001146602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02540658,"threshold_uncertainty_score":0.6404487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203882899452377,"score_gpt":0.2572574379673053,"score_spread":0.2452186089727815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}