{"id":"W2142817787","doi":"10.1177/1087057103262841","title":"A Miniaturized Column Chromatography Method for Measuring Receptor-Mediated Inositol Phosphate Accumulation","year":2004,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Purdue Pharma (Canada)","funders":"","keywords":"Inositol phosphate; Chromatography; Inositol; Chemistry; Receptor; Phospholipase C; Metabotropic receptor; Affinity chromatography; Biochemistry; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002658926,0.0001871641,0.0001877988,0.00007909977,0.0001411978,0.00008721655,0.0001236087,0.000181418,0.00001053802],"category_scores_gemma":[0.00009631478,0.0001912854,0.0002182342,0.000181943,0.0000395756,0.0000257503,0.00005045967,0.00006494517,0.000007649116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003306631,"about_ca_system_score_gemma":0.0001242943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003645988,"about_ca_topic_score_gemma":0.00002734019,"domain_scores_codex":[0.998855,0.00004878814,0.0002642323,0.0003892745,0.0001705022,0.0002722168],"domain_scores_gemma":[0.9994135,0.00002395333,0.0001448015,0.0002423516,0.00009302969,0.0000823083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003329063,0.00006942621,0.0004117002,0.00004879513,0.0000935855,0.000001124358,0.00004903416,0.0007559547,0.9966934,0.0006216183,0.0003147789,0.0006077136],"study_design_scores_gemma":[0.002880214,0.000146987,0.001110369,0.00007080629,0.00002998767,0.000004306242,0.00003392126,0.0003294763,0.9802552,0.0008360413,0.01400661,0.0002960874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8018205,0.001088931,0.1955641,0.0001778577,0.0002375617,0.0008521041,0.00009046859,0.00005398805,0.0001145829],"genre_scores_gemma":[0.9409969,0.00005697671,0.05725696,0.0002726593,0.000281038,0.0001756205,0.0007800834,0.00004041712,0.0001392921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1391765,"threshold_uncertainty_score":0.7800393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110976632543947,"score_gpt":0.2866191311156439,"score_spread":0.2655093647902044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}