{"id":"W2142833256","doi":"10.1007/s12016-009-8172-8","title":"Epigenetic Therapeutics in Autoimmune Disease","year":2009,"lang":"en","type":"review","venue":"Clinical Reviews in Allergy & Immunology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Ministerio de Economía y Competitividad","keywords":"Epigenetics; DNA demethylation; DNA methylation; Histone; Histone deacetylase; Systemic lupus erythematosus; Biology; Demethylation; Epigenomics; Disease; Epigenetic therapy; DNA; Genetics; Bioinformatics; Medicine; Immunology; Gene; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009747549,0.001159082,0.001608516,0.001473815,0.0003615353,0.0008086606,0.001064103,0.001618003,0.0057578],"category_scores_gemma":[0.0008702112,0.0003257919,0.0004563061,0.001028613,0.0007940741,0.001080481,0.0009680594,0.00277937,0.002720448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000583129,"about_ca_system_score_gemma":0.000711535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005058202,"about_ca_topic_score_gemma":0.001698622,"domain_scores_codex":[0.9997826,0.000048764,0.00002162973,0.00003243414,0.00009170198,0.00002291046],"domain_scores_gemma":[0.9997365,0.0001301616,0.00003071408,0.00001514256,0.00005603896,0.00003147628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001394912,0.0001110543,0.0001026032,0.00444745,0.00007522252,0.0002739988,0.00004667168,0.0003179087,0.004034478,0.005744072,0.08721448,0.8974926],"study_design_scores_gemma":[0.00007521149,0.0001027396,0.0004626422,0.001032628,0.00007988237,0.0009052563,0.00002671474,0.0001273697,0.0008626952,0.003702147,0.9926074,0.00001535533],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009767098,0.9960613,0.0004108123,0.0006701009,0.001225007,0.000009740656,0.00001269324,0.00001741601,0.00149533],"genre_scores_gemma":[0.001441287,0.9924018,0.0005385349,0.0008683873,0.001699117,0.00002686965,0.00003670388,0.000004116431,0.002983186],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0057578,"threshold_uncertainty_score":0.01926178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144661301965779,"score_gpt":0.4344015898095369,"score_spread":0.3199354596129591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}