{"id":"W2142850134","doi":"10.1002/1521-3773(20020703)41:13<2338::aid-anie2338>3.0.co;2-m","title":"Stereoselective Formation of Quaternary Carbon Centers: Alkylation ofα,α-Disubstituted Amide Enolates","year":2002,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Alkylation; Amide; Chemistry; Stereoselectivity; Chelation; Quaternary carbon; Carbon fibers; Medicinal chemistry; Stereochemistry; Organic chemistry; Catalysis; Computer science; Enantioselective synthesis; Algorithm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003944513,0.0006104084,0.0002806313,0.0002403629,0.0002168587,0.0002648058,0.0003229454,0.0002554167,0.001735101],"category_scores_gemma":[0.0003507306,0.0001655239,0.0001782263,0.0002718641,0.0002094363,0.0002776808,0.0002644589,0.0004693102,0.001013985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000246001,"about_ca_system_score_gemma":0.0002875142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005070886,"about_ca_topic_score_gemma":0.001275691,"domain_scores_codex":[0.9997614,0.00004721222,0.00003003122,0.00004353265,0.00004921816,0.00006863943],"domain_scores_gemma":[0.9997383,0.00003938556,0.00004834132,0.00004217454,0.00006752615,0.00006421081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009658207,0.00001573982,0.0001183605,0.00005598506,0.000005825482,0.00009401727,0.00003724593,0.00009695749,0.9963633,0.0002565662,0.0000845275,0.002774807],"study_design_scores_gemma":[0.000007386792,0.00007259205,0.0002550663,0.000001882753,0.000004731615,0.0001178444,0.000006762966,0.0001075738,0.997946,0.00002312752,0.001454051,0.000003058266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670013,0.001396353,0.01511295,0.0001350618,0.0000897438,0.0001220994,0.0008713749,0.0003248234,0.01494612],"genre_scores_gemma":[0.9870238,0.001235188,0.006441569,0.00006499212,0.00001337984,0.00002439167,0.0005376661,0.00008470712,0.004574298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001735101,"threshold_uncertainty_score":0.005804479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939674209824037,"score_gpt":0.2340913752933078,"score_spread":0.2146946331950674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}