{"id":"W2142907545","doi":"10.1128/mcb.01450-08","title":"The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Center for Research Resources; U.S. Public Health Service","keywords":"Neurofibromin 1; Biology; GTPase-activating protein; Saccharomyces cerevisiae; Cell biology; Mutant; Ubiquitin; Signal transducing adaptor protein; Ultrabithorax; Yeast; Signal transduction; Genetics; G protein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146174,0.0001871309,0.0001856767,0.00006400568,0.0001168189,0.00003918709,0.00009293768,0.0002681852,0.000004352984],"category_scores_gemma":[0.0000863053,0.0001530167,0.00003191532,0.00009480269,0.0003523271,0.000004678398,0.0001347243,0.0002340322,6.691021e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004332614,"about_ca_system_score_gemma":0.00002311277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007466698,"about_ca_topic_score_gemma":0.000285947,"domain_scores_codex":[0.998781,0.0001999301,0.0002330326,0.0004536618,0.00005530963,0.0002770357],"domain_scores_gemma":[0.9995628,0.00001399281,0.00008749433,0.0002249252,0.00002739358,0.0000833892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005832235,0.00002260517,0.007453007,0.0000134885,0.00001061626,0.00001736709,0.00003932876,0.000001858111,0.9894816,0.0007310904,0.0000199038,0.002150845],"study_design_scores_gemma":[0.001303034,0.0002019267,0.01638759,0.00002448059,0.00000902541,0.00002435393,0.0000828279,0.0002226135,0.969607,0.001059986,0.01079616,0.0002810402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993713,0.004679204,0.0006209504,0.0004410919,0.00004040792,0.0003921538,0.0000150359,0.000007616213,0.00009049889],"genre_scores_gemma":[0.9992313,0.0001738129,0.0001693879,0.0001569806,0.000027893,0.00004238946,0.00007273818,0.00001938992,0.0001061349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0198746,"threshold_uncertainty_score":0.6239839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004713364703880537,"score_gpt":0.2133773524581734,"score_spread":0.2086639877542929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}