{"id":"W2142907545","doi":"10.1128/mcb.01450-08","title":"The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Center for Research Resources; U.S. Public Health Service","keywords":"Neurofibromin 1; Biology; GTPase-activating protein; Saccharomyces cerevisiae; Cell biology; Mutant; Ubiquitin; Signal transducing adaptor protein; Ultrabithorax; Yeast; Signal transduction; Genetics; G protein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008222651,0.0005832254,0.0002340552,0.0005718507,0.0002149074,0.0004899977,0.0001665667,0.0003564089,0.00130477],"category_scores_gemma":[0.0001272847,0.0002403879,0.0002277397,0.0003043633,0.0002038374,0.0001182725,0.000365723,0.0003151021,0.0005573945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237032,"about_ca_system_score_gemma":0.0001215229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009598081,"about_ca_topic_score_gemma":0.0008198192,"domain_scores_codex":[0.9998997,0.00001074054,0.000008226216,0.00004400584,0.0000256117,0.00001168366],"domain_scores_gemma":[0.9999288,0.000007184321,0.00003418647,0.000007657653,0.000007073964,0.00001504159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006921994,0.00003484609,0.008560522,0.00008436427,0.00008457823,0.001499348,0.00009753099,0.0003584061,0.9799373,0.0005321597,0.0002882039,0.00783065],"study_design_scores_gemma":[0.0002531996,0.0003851176,0.457904,0.00009408399,0.0004311323,0.02666913,0.0003670632,0.002659448,0.4740949,0.001520198,0.03555159,0.00007026862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924016,0.003140193,0.001833598,0.0001219037,0.00001827398,0.000007626655,0.000844503,0.0001447911,0.001487602],"genre_scores_gemma":[0.9944417,0.001329013,0.001243385,0.00008387465,0.000008453808,0.0000128461,0.00113776,0.0000411031,0.001702008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130477,"threshold_uncertainty_score":0.004364908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004713364703880537,"score_gpt":0.2133773524581734,"score_spread":0.2086639877542929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}