{"id":"W2142945288","doi":"10.1124/mol.104.005769","title":"Expression of the Retinoic Acid-Metabolizing Enzyme CYP26A1 Limits Programmed Cell Death","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Retinoic acid; Apoptosis; Programmed cell death; Carcinogenesis; Biology; Enzyme; Cell culture; Cancer cell; Biochemistry; Chemistry; Cancer research; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002437515,0.0002685797,0.0002485535,0.00005148603,0.0001245198,0.00001638583,0.0006567368,0.0002827845,0.00007961618],"category_scores_gemma":[0.00006215621,0.0002099049,0.0002284199,0.0001854842,0.0001756155,0.000006915727,0.0002910958,0.0002579227,0.00001407677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002540966,"about_ca_system_score_gemma":0.0001747847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003216396,"about_ca_topic_score_gemma":0.000001282288,"domain_scores_codex":[0.9981337,0.0002915732,0.0003723325,0.0004902969,0.0002429677,0.0004691719],"domain_scores_gemma":[0.9990117,0.00001484104,0.0002461083,0.000471352,0.0001443393,0.0001116536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008254233,0.0001641489,0.0005710182,0.00006426786,0.00003636438,0.000009232495,0.00005678626,0.0002999108,0.9948705,0.00004745925,0.00190488,0.001892912],"study_design_scores_gemma":[0.001038917,0.0001258942,0.000122456,0.00001435817,0.00009191396,0.00002662842,0.00002495444,0.00007398114,0.9284477,0.00003432917,0.06978168,0.0002171552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845955,0.007835127,0.002450452,0.0003182522,0.0003829632,0.0004389474,0.000006966039,0.0000273879,0.003944451],"genre_scores_gemma":[0.994812,0.0002847311,0.002562068,0.001179662,0.0003777307,0.00006782937,0.00003230363,0.00004856888,0.0006351634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06787679,"threshold_uncertainty_score":0.8559675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112317090034254,"score_gpt":0.2642142233002097,"score_spread":0.2551019062101755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}