{"id":"W2142971789","doi":"10.1124/jpet.111.184671","title":"Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; University of California, Davis; University of Toronto; University of Michigan","keywords":"Toxicity; Xenobiotic; Olfactory mucosa; Pharmacology; Biology; Chemistry; Respiratory tract; Respiratory system; Biochemistry; Enzyme; Olfactory system; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351337,0.00148784,0.0008832226,0.003917084,0.001102922,0.001202635,0.001392467,0.002428444,0.006845288],"category_scores_gemma":[0.0007645809,0.001378694,0.001498976,0.0007628367,0.001391618,0.001093054,0.0007662121,0.003135687,0.002187648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007560523,"about_ca_system_score_gemma":0.000521189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147976,"about_ca_topic_score_gemma":0.002868457,"domain_scores_codex":[0.9990042,0.0001012988,0.0001611417,0.0002650061,0.0003211679,0.0001472423],"domain_scores_gemma":[0.9988548,0.0002137085,0.0003030456,0.0001728836,0.0001188807,0.0003367786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003658321,0.0002958595,0.0006477307,0.00008442841,0.00003974621,0.0007837111,0.0001255575,0.0002179096,0.9920776,0.002383428,0.0004019825,0.0025761],"study_design_scores_gemma":[0.0003832155,0.0009890089,0.009355608,0.0000966603,0.0002341417,0.005533143,0.000286261,0.002910923,0.9505218,0.001215204,0.02840314,0.00007095436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9042277,0.004155472,0.0641318,0.002333462,0.0005515324,0.001348862,0.01602759,0.0009069796,0.006316473],"genre_scores_gemma":[0.8739135,0.005110973,0.0522657,0.0009099627,0.0002281443,0.002139585,0.01423872,0.00113376,0.05005974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006845288,"threshold_uncertainty_score":0.02289981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2379826961021493,"score_gpt":0.4333925461781499,"score_spread":0.1954098500760005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}