{"id":"W2143004298","doi":"10.1111/ijs.12486","title":"Rationale, Design, and Progress of the ENhanced Control of Hypertension ANd Thrombolysis Stroke Study (ENCHANTED) Trial: An International Multicenter 2 × 2 Quasi-Factorial Randomized Controlled Trial of Low- vs. Standard-Dose rt-PA and Early Intensive vs. Guideline-Recommended Blood Pressure Lowering in Patients with Acute Ischaemic Stroke Eligible for Thrombolysis Treatment","year":2015,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Medical Research Council; National Institute for Health and Care Research; National Health and Medical Research Council; Pfizer","keywords":"Medicine; Thrombolysis; Randomization; Randomized controlled trial; Stroke (engine); Blood pressure; Clinical endpoint; Clinical trial; Internal medicine; Guideline; Surgery; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02901047,0.00446025,0.005039594,0.0009580334,0.001489118,0.002981275,0.002781851,0.004749555,0.01374169],"category_scores_gemma":[0.02035355,0.002073074,0.003110439,0.000982643,0.004350153,0.001986968,0.001249168,0.003994588,0.003162897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001382251,"about_ca_system_score_gemma":0.006134504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007894585,"about_ca_topic_score_gemma":0.001446414,"domain_scores_codex":[0.9767655,0.01670904,0.001214604,0.002608652,0.001442799,0.001259447],"domain_scores_gemma":[0.9936154,0.001885485,0.00135035,0.0009038316,0.0007542737,0.001490719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9477075,0.01170427,0.004509219,0.005119394,0.002848709,0.0002639622,0.0003286671,0.0008841943,0.001648616,0.0041962,0.00453413,0.01625516],"study_design_scores_gemma":[0.9390491,0.04077949,0.004252043,0.0007335799,0.002100067,0.0000978313,0.00008813794,0.001537718,0.0004407923,0.002760706,0.008062855,0.00009769985],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.1198475,0.009415669,0.01007099,0.006359178,0.0061883,0.8348809,0.004853721,0.0003174234,0.008066262],"genre_scores_gemma":[0.204815,0.001681286,0.01884195,0.007044154,0.002124013,0.759887,0.001626781,0.00004669898,0.003933232],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02901047,"threshold_uncertainty_score":0.1534238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797694843511005,"score_gpt":0.2939792841738121,"score_spread":0.2760023357387021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}