{"id":"W2143004298","doi":"10.1111/ijs.12486","title":"Rationale, Design, and Progress of the ENhanced Control of Hypertension ANd Thrombolysis Stroke Study (ENCHANTED) Trial: An International Multicenter 2 × 2 Quasi-Factorial Randomized Controlled Trial of Low- vs. Standard-Dose rt-PA and Early Intensive vs. Guideline-Recommended Blood Pressure Lowering in Patients with Acute Ischaemic Stroke Eligible for Thrombolysis Treatment","year":2015,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Medical Research Council; National Institute for Health and Care Research; National Health and Medical Research Council; Pfizer","keywords":"Medicine; Thrombolysis; Randomization; Randomized controlled trial; Stroke (engine); Blood pressure; Clinical endpoint; Clinical trial; Internal medicine; Guideline; Surgery; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001518981,0.0003746679,0.002485538,0.0005317443,0.00003720989,0.00005351562,0.0003139032,0.0001142551,0.00001039842],"category_scores_gemma":[0.001188691,0.0002252648,0.0003872409,0.00008717893,0.0002476899,0.0004082552,0.0001321178,0.0002074179,3.929247e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122773,"about_ca_system_score_gemma":0.0002407561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006752687,"about_ca_topic_score_gemma":0.00001194318,"domain_scores_codex":[0.9953742,0.0003391184,0.002208369,0.0003736078,0.00149233,0.0002123919],"domain_scores_gemma":[0.9918899,0.0007336795,0.002463715,0.0002532801,0.004513155,0.0001462562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9415106,0.003113748,0.02628905,0.00002732511,0.01812028,0.0000147287,0.001500946,0.0001415976,0.008724669,0.000008577305,0.00003666263,0.0005118267],"study_design_scores_gemma":[0.9507483,0.01763976,0.003603828,0.0003305666,0.006737152,0.00001397649,0.0008684915,0.001961353,0.01790387,0.0000110032,0.00002287501,0.0001588681],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811401,0.0002224323,0.006481397,0.0005560932,0.001180645,0.01002732,0.0003745742,0.000007044513,0.0000103757],"genre_scores_gemma":[0.9962545,0.0002139433,0.00284988,0.00005124295,0.0002828653,0.0002470457,0.00002468481,0.00003110516,0.00004474198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02268522,"threshold_uncertainty_score":0.9186031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797694843511005,"score_gpt":0.2939792841738121,"score_spread":0.2760023357387021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}