{"id":"W2143013795","doi":"10.1634/theoncologist.2015-0008","title":"Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials","year":2015,"lang":"en","type":"article","venue":"The Oncologist","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical trial; Oncology; Cancer; Pharmacology; Intensive care medicine; Internal medicine; Medical physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.0858764,0.0001987768,0.001902166,0.00007550434,0.0000587676,0.00002162523,0.0005427003,0.0002817732,0.0001369402],"category_scores_gemma":[0.5888545,0.0001253266,0.0002856686,0.0003106553,0.0006897819,0.00004566515,0.0001508541,0.0005099968,0.000006157949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052738,"about_ca_system_score_gemma":0.0002404825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003262133,"about_ca_topic_score_gemma":0.0009706473,"domain_scores_codex":[0.9887731,0.005957372,0.004118157,0.0003870615,0.0003155613,0.0004487649],"domain_scores_gemma":[0.6753764,0.3223282,0.001365934,0.0005255276,0.0001910032,0.0002130225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0172244,0.0165799,0.03536968,0.001394629,0.0005674566,0.00008776113,0.001761147,0.000319251,0.003119816,0.621682,0.02967795,0.272216],"study_design_scores_gemma":[0.02567507,0.001281935,0.0008961904,0.0002119712,0.0002608516,4.087341e-7,0.0002097055,0.002187659,0.00149687,0.9604361,0.007119306,0.0002239251],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331757,0.0008564728,0.03318797,0.01361251,0.003935706,0.00929845,0.0007377764,0.0001580836,0.005037277],"genre_scores_gemma":[0.7115814,0.000156446,0.2844199,0.0009855578,0.001634609,0.0009033988,0.000002974493,0.00006115763,0.0002545872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5029781,"threshold_uncertainty_score":0.9412826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9526026533308177,"score_gpt":0.7811456566783852,"score_spread":0.1714569966524325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}