{"id":"W2143112201","doi":"10.1093/toxsci/kfq096","title":"3-Methylcholanthrene Induces Differential Recruitment of Aryl Hydrocarbon Receptor to Human Promoters","year":2010,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Chromatin immunoprecipitation; Acetylation; Histone; Transcription factor; Chromatin; Nuclear receptor; DNA methylation; Promoter; Chemistry; Aryl hydrocarbon receptor nuclear translocator; Receptor; Transcriptional regulation; Methylation; Gene; Molecular biology; Gene expression; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008846637,0.0002064127,0.0002764713,0.00007066099,0.0003012331,0.00006078221,0.0009785698,0.0001643331,0.01235388],"category_scores_gemma":[0.0003811966,0.0001359759,0.00006225597,0.0007356653,0.00124397,0.0002009884,0.0004429936,0.0002950014,0.0002972574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009681276,"about_ca_system_score_gemma":0.00002806675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009327465,"about_ca_topic_score_gemma":0.0001976771,"domain_scores_codex":[0.9976761,0.00005709604,0.0003854999,0.0005935255,0.0007155918,0.0005722029],"domain_scores_gemma":[0.9990957,0.00009263712,0.0001652328,0.0002773609,0.000002490925,0.0003666164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001102394,0.0002215053,0.004105412,8.067053e-7,0.000004158863,0.00000166704,0.0001858118,0.000004681397,0.9548174,0.0001317784,0.0001158652,0.04039996],"study_design_scores_gemma":[0.0001851236,0.001230743,0.3097442,0.000007761254,0.000007667662,0.000005051152,0.00005562071,0.00002771476,0.6869802,0.000742836,0.0007885433,0.0002245087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992161,0.000004162554,0.00003107258,0.001044783,0.0004836136,0.0005724651,0.00002018273,0.00007062907,0.005612035],"genre_scores_gemma":[0.9973779,0.000002873139,0.002139595,0.0002246597,0.00007663779,0.00002589664,6.106002e-7,0.000007733584,0.0001441288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3056388,"threshold_uncertainty_score":0.9885489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06062538454683616,"score_gpt":0.3259434170508059,"score_spread":0.2653180325039698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}