{"id":"W2143112201","doi":"10.1093/toxsci/kfq096","title":"3-Methylcholanthrene Induces Differential Recruitment of Aryl Hydrocarbon Receptor to Human Promoters","year":2010,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Chromatin immunoprecipitation; Acetylation; Histone; Transcription factor; Chromatin; Nuclear receptor; DNA methylation; Promoter; Chemistry; Aryl hydrocarbon receptor nuclear translocator; Receptor; Transcriptional regulation; Methylation; Gene; Molecular biology; Gene expression; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325978,0.000174321,0.0001815905,0.0003204654,0.000125319,0.0002581774,0.0001063969,0.0001273461,0.001517165],"category_scores_gemma":[0.0001885798,0.0001644446,0.0003050364,0.0002420855,0.0001166977,0.00007123129,0.0002659434,0.0002939204,0.0006072888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540188,"about_ca_system_score_gemma":0.0001937944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143474,"about_ca_topic_score_gemma":0.002107668,"domain_scores_codex":[0.9997608,0.00002806663,0.00001258259,0.00006616375,0.00006727289,0.00006514009],"domain_scores_gemma":[0.9998667,0.00003746093,0.00002236095,0.00002483355,0.00002087341,0.00002775158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490431,0.00001673743,0.0004675654,0.00001657219,0.000006008396,0.00002910747,0.00002450737,0.00001760773,0.9981797,0.00001907567,0.00004245848,0.00103165],"study_design_scores_gemma":[0.00002439599,0.0003561281,0.05483237,0.000009492695,0.00002007142,0.0003342259,0.00007308249,0.000504824,0.9387649,0.00006166335,0.005009553,0.000009270048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929067,0.002800017,0.001709729,0.00007333756,0.00004125376,0.00003229813,0.0009860675,0.00008425033,0.00136632],"genre_scores_gemma":[0.9915256,0.001453333,0.001152454,0.00009819608,0.00001669635,0.00005849135,0.002102974,0.00002546079,0.003566779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517165,"threshold_uncertainty_score":0.005075455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06062538454683616,"score_gpt":0.3259434170508059,"score_spread":0.2653180325039698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}