{"id":"W2143139829","doi":"10.1152/ajpheart.01084.2010","title":"Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"mTORC1; Calcineurin; PI3K/AKT/mTOR pathway; Vascular smooth muscle; Contractility; Chemistry; P70-S6 Kinase 1; Phosphorylation; Cell biology; Biology; Pharmacology; Endocrinology; Internal medicine; Signal transduction; Transplantation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127395,0.0003181745,0.0002772144,0.0001884061,0.0001413908,0.0001426436,0.0001524773,0.0001962779,0.0009781175],"category_scores_gemma":[0.00007587473,0.0001157899,0.0002207635,0.000120995,0.000200898,0.00009999132,0.0001510297,0.0006306998,0.0002139557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872248,"about_ca_system_score_gemma":0.0002197517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004280648,"about_ca_topic_score_gemma":0.0007812041,"domain_scores_codex":[0.9999105,0.00001841267,0.000009721116,0.00001271805,0.00001516629,0.00003346342],"domain_scores_gemma":[0.9999259,0.0000116691,0.00002661807,0.000007961021,0.00000707283,0.00002086479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002767988,0.00007549491,0.0001559416,0.00004946325,0.00001105905,0.00004684239,0.00001243463,0.00006604601,0.9971291,0.00007254544,0.0001298811,0.001974396],"study_design_scores_gemma":[0.0000268405,0.001283576,0.008017713,0.000008028424,0.0000215866,0.0001559451,0.00001937509,0.0008231776,0.9876645,0.00003334179,0.001940931,0.000004996204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941038,0.003131935,0.0009223943,0.0001367513,0.00006859475,0.00002326013,0.0002143694,0.0001101852,0.001288768],"genre_scores_gemma":[0.9950292,0.001989311,0.0008642418,0.00005848592,0.00002418193,0.00004319965,0.0004540823,0.00001050757,0.001526822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009781175,"threshold_uncertainty_score":0.003272116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575146805870015,"score_gpt":0.2462423426455435,"score_spread":0.2304908745868434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}