{"id":"W2143149828","doi":"10.1093/cercor/bht364","title":"Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study","year":2014,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Fetus; Thyroid; Endocrinology; Internal medicine; Hormone; Microarray; Gene expression; Cerebral cortex; microRNA; Thyroid function; Biology; Gene; Medicine; Pregnancy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001038538,0.0004609541,0.0005533536,0.0001625424,0.0004535647,0.00009878242,0.0003989531,0.0001213988,0.00006578987],"category_scores_gemma":[0.0000603078,0.0002331637,0.0002583129,0.0004354324,0.0003042918,0.0001357827,0.00007360581,0.0004854411,0.00002446631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006671868,"about_ca_system_score_gemma":0.000114733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002810107,"about_ca_topic_score_gemma":0.0005999298,"domain_scores_codex":[0.9968532,0.0005499566,0.0006812873,0.0005991093,0.0007509383,0.0005655154],"domain_scores_gemma":[0.9986752,0.0001762898,0.0001791955,0.0006778191,0.000125346,0.0001661136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03291772,0.004743086,0.3880232,0.0001253314,0.001449157,0.0003252139,0.03117607,0.00005361389,0.5332963,0.0005607954,0.001525401,0.005804173],"study_design_scores_gemma":[0.00704332,0.005580767,0.9767467,0.00003475133,0.0005400423,0.000577622,0.007979727,0.0002137214,0.0005983,0.0002214591,0.0002463252,0.0002172045],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909995,0.001981265,0.0001100531,0.003767215,0.0001945135,0.002619924,0.000115827,0.00004493295,0.0001667656],"genre_scores_gemma":[0.9981266,0.00002247013,0.00013289,0.000913501,0.0001494976,0.0001781543,0.00006507932,0.00005372725,0.0003580356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5887236,"threshold_uncertainty_score":0.950814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024210715174742,"score_gpt":0.232789995902369,"score_spread":0.2225478887506216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}